Response of rat intracranial 9L gliosarcoma to microbeam radiation therapy

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dc.contributor.authorDilmanian, F. A.en
dc.contributor.authorButton, T. M.en
dc.contributor.authorLe Duc, G.en
dc.contributor.authorZhong, N.en
dc.contributor.authorPena, L. A.en
dc.contributor.authorSmith, J. A.en
dc.contributor.authorMartinez, S. R.en
dc.contributor.authorBacarian, T.en
dc.contributor.authorTammam, J.en
dc.contributor.authorRen, B.en
dc.contributor.authorFarmer, P. M.en
dc.contributor.authorKalef-Ezra, J.en
dc.contributor.authorMicca, P. L.en
dc.contributor.authorNawrocky, M. M.en
dc.contributor.authorNiederer, J. A.en
dc.contributor.authorRecksiek, F. P.en
dc.contributor.authorFuchs, A.en
dc.contributor.authorRosen, E. M.en
dc.date.accessioned2015-11-24T18:53:50Z
dc.date.available2015-11-24T18:53:50Z
dc.identifier.issn1522-8517-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18616
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectBrain Neoplasms/diagnosis/pathology/*radiotherapyen
dc.subjectComputer Simulationen
dc.subjectGliosarcoma/diagnosis/pathology/*radiotherapyen
dc.subjectMagnetic Resonance Imagingen
dc.subjectMaleen
dc.subjectMonte Carlo Methoden
dc.subjectNeoplasm Transplantationen
dc.subjectRadiometryen
dc.subjectRadiotherapy/methodsen
dc.subjectRatsen
dc.subjectRats, Inbred F344en
dc.subjectSurvival Analysisen
dc.subjectTumor Cells, Cultureden
dc.titleResponse of rat intracranial 9L gliosarcoma to microbeam radiation therapyen
heal.abstractRadiotherapeutic doses for malignant gliomas are generally palliative because greater, supposedly curative doses would impart clinically unacceptable damage to nearby vital CNS tissues. To improve radiation treatment for human gliomas, we evaluated microbeam radiation therapy, which utilizes an array of parallel, microscopically thin (<100 microm) planar beams (microbeams) of synchrotron-generated X rays. Rats with i.c. 9L gliosarcoma tumors were exposed laterally to a single microbeam, 27 pm wide and 3.8 mm high, stepwise, to produce irradiation arrays with 50, 75, or 100 microm of on-center beam spacings and 150, 250, 300, or 500 Gy of in-slice, skin-entrance, single-exposure doses. The resulting array size was 9 mm wide and 10.4 mm high (using three 3.8-mm vertical tiers); the beam's median energy was -70 keV. When all data were collated, the median survival was 70 days; no depletion of nerve cells was observed. However, when data from the highest skin-entrance dose and/or the smallest microbeam spacings were excluded, the median survival time of the subset of rats was 170 days, and no white matter necrosis was observed. Others have reported unilateral single-exposure broad-beam irradiation of i.c. 9L gliosarcomas at 22.5 Gy with a median survival of only -34 days and with severe depletion of neurons. These results suggest that the therapeutic index of unidirectional microbeams is larger than that of the broad beams and that an application for microbeam radiation therapy in treating certain malignant brain tumors may be found in the future.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/11772430-
heal.identifier.secondaryhttp://neuro-oncology.oxfordjournals.org/content/4/1/26.full.pdf-
heal.journalNameNeuro Oncolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2002-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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