MRI evaluation of the basal ganglia size and iron content in patients with Parkinson's disease
Φόρτωση...
Ημερομηνία
Συγγραφείς
Kosta, P.
Argyropoulou, M. I.
Markoula, S.
Konitsiotis, S.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Neurol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVE: To evaluate by MRI the area size and the degree of iron accumulation in basal ganglia nuclei that are implicated in the pathogenesis of Parkinson's disease (PD). METHODS: 40 patients with idiopathic PD and 40 controls were examined on a 1. 5 Tesla MR imager, using a multiecho SE sequence 2000/20, 40, 60, 80, 100, 120, 140, 160 (TR/TE). The T2 relaxation time (T2) and the area of substantia nigra zona compacta (SNc), substantia nigra zona reticulata (SNr), putamen (Pu), globus pallidus external (GPe), globus pallidus internal (GPi), caudate nucleus (CN), locus coeruleus (LC) and subthalamic nucleus (STN) were assessed. RESULTS: The T2 of SNc (76. 8 +/- 6. 0) was lower and of Pu (79.5 +/- 6.0) and GPe (69.5 +/- 7.0) was higher in patients than in controls (78.6 +/- 3.8, 77.4 +/- 3.9 and 67.3 +/- 5.7, respectively), p < 0.05. The area of CN (125.9 +/- 20.2) and Pu (201.5 +/- 48.7) was higher in patients than in controls (110.7 +/- 21.5 and 180.1 +/- 41.1, respectively), p < 0.05. A more pronounced decrease in the T2 of SNc (73.6 +/- 8.9) was observed when the more affected side of patients was evaluated separately. In patients with disease duration > 5 years the T2 of STN (71.5 +/- 6.3) was lower and the area of Pu was higher (215.3 +/- 54.9) compared with those with disease duration < or = 5 years (75.8 +/- 10.9 and 190.9 +/- 41.0 respectively), p < 0.05. CONCLUSIONS: These findings suggest that dysfunction of the basal ganglia circuitry in PD may affect iron content not only in SNc but in STN, Pu and GPe as well. Compensatory sprouting of the remaining dopaminergic fibers could account for the increased area of the CN and Pu.
Περιγραφή
Λέξεις-κλειδιά
Adult, Age of Onset, Aged, Basal Ganglia/*pathology, Case-Control Studies, Female, Functional Laterality, Humans, Iron/*metabolism, *Magnetic Resonance Imaging, Male, Middle Aged, Parkinson Disease/*metabolism/*pathology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/15981079
http://www.springerlink.com/content/r7h45528w3776hjl/fulltext.pdf
http://www.springerlink.com/content/r7h45528w3776hjl/fulltext.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής