Amplification and co-regulators of androgen receptor gene in prostate cancer
| dc.contributor.author | Golias, Ch | en |
| dc.contributor.author | Iliadis, I. | en |
| dc.contributor.author | Peschos, D. | en |
| dc.contributor.author | Charalabopoulos, K. | en |
| dc.date.accessioned | 2015-11-24T19:36:43Z | |
| dc.date.available | 2015-11-24T19:36:43Z | |
| dc.identifier.issn | 1812-9269 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23928 | |
| dc.rights | Default Licence | - |
| dc.subject | *Gene Expression Regulation, Neoplastic | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Mutation | en |
| dc.subject | Prostatic Neoplasms/*genetics/immunology/*metabolism/physiopathology | en |
| dc.subject | Receptors, Androgen/*genetics/immunology/*metabolism | en |
| dc.title | Amplification and co-regulators of androgen receptor gene in prostate cancer | en |
| heal.abstract | Prostate cancer is the second most common malignancy among males after lung cancer. The growth of prostate cancer cells depends on the presence of androgens, a group of steroid hormones that include testosterone and its more active metabolite dihydrotestoste-rone. Most prostate cancers are androgen-dependent and respond to the antiandrogens or androgen-deprivation therapy. However, the progression to an androgen-independent stage occurs frequently. Possible mechanisms that could be involved in the development of hormone resistant prostate cancer causes including androgen receptor (AR) mutations, AR amplification/over expression, interaction between AR and other growth factors, and enhanced signaling in a ligand-independent manner are discussed. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/19300409 | - |
| heal.journalName | Exp Oncol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2009 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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