Modifications of drug metabolism by disulfiram and diethyldithiocarbamate. II. D-Glucuronic acid pathway
Φόρτωση...
Ημερομηνία
Συγγραφείς
Marselos, M.
Lang, M.
Torronen, R.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Chem Biol Interact
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Hepatic enzymes connected with the formation and metabolism of free D-glucuronic acid were affected in rats after treatment with disulfiram or diethyldithiocarbamate (300 mg/kg, intragastrically, per day, 4 X). The activities of UDPglucose dehydrogenase, UDPglucuronic acid pyrophosphatase, UDPglucuronosyltransferase and L-gulonate dehydrogenase were enhanced, while those of glucose-6-phosphate dehydrogenase, beta-glucuronidase and D-glucuronolactone dehydrogenase were inhibited. These changes were more pronounced with disulfiram than diethyldithiocarbamate. Treatment with phenobarbital (80 mg/kg, i.p., per day, 4 X) enhanced UDP glucuronosyl-transferase, but brought about different effects on the other enzymes. Concurrent administration of phenobarbital with disulfiram or diethyldithiocarbamate led to potentiation or antagonism of the primary effects of each compound when given alone. The results suggest that activation of the D-glucuronic acid pathway may proceed in various ways, and that it is not necessarily followed by a simultaneous induction of the microsomal mixed-function oxygenase activity.
Περιγραφή
Λέξεις-κλειδιά
Alcohol Oxidoreductases/metabolism, Animals, Disulfiram/*pharmacology, Ditiocarb/*pharmacology, Female, Glucosephosphate Dehydrogenase/metabolism, Glucuronates/*metabolism, Glucuronidase/metabolism, Glucuronosyltransferase/metabolism, Liver/drug effects/*enzymology, Phenobarbital/pharmacology, Pyrophosphatases/metabolism, Rats, Sugar Acids, Thiocarbamates/*pharmacology, Uridine Diphosphate Glucose Dehydrogenase/metabolism, Uridine Diphosphate Glucuronic Acid
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/187353
http://ac.els-cdn.com/0009279776901538/1-s2.0-0009279776901538-main.pdf?_tid=c368daeb54f5eb6c3a434c7893fe07a9&acdnat=1332744205_035b04cd04fbe84891786c6874410ce8
http://ac.els-cdn.com/0009279776901538/1-s2.0-0009279776901538-main.pdf?_tid=c368daeb54f5eb6c3a434c7893fe07a9&acdnat=1332744205_035b04cd04fbe84891786c6874410ce8
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής