Risk factors for first-ever acute ischemic non-embolic stroke in elderly individuals

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dc.contributor.authorMilionis, H. J.en
dc.contributor.authorLiberopoulos, E.en
dc.contributor.authorGoudevenos, J.en
dc.contributor.authorBairaktari, E. T.en
dc.contributor.authorSeferiadis, K.en
dc.contributor.authorElisaf, M. S.en
dc.date.accessioned2015-11-24T18:53:21Z
dc.date.available2015-11-24T18:53:21Z
dc.identifier.issn0167-5273-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18546
dc.rightsDefault Licence-
dc.subjectAcute Diseaseen
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectBrain Ischemia/blood/*complications/epidemiologyen
dc.subjectCase-Control Studiesen
dc.subjectCholesterol/blooden
dc.subjectFemaleen
dc.subjectFibrinogen/metabolismen
dc.subjectGreece/epidemiologyen
dc.subjectHumansen
dc.subjectHyperlipidemias/blood/complicationsen
dc.subjectIncidenceen
dc.subjectMaleen
dc.subjectRetrospective Studiesen
dc.subjectRisk Factorsen
dc.subjectSmoking/adverse effects/blooden
dc.subjectStroke/blood/epidemiology/*etiologyen
dc.subjectUric Acid/blooden
dc.titleRisk factors for first-ever acute ischemic non-embolic stroke in elderly individualsen
heal.abstractBACKGROUND: Stroke is a leading cause of mortality and subsequent serious long-term physical and mental disability among survivors. In the elderly, ischemic stroke accounts for more than 80% of all strokes. OBJECTIVES: To identify major risk factors for a first-ever acute ischemic/non-embolic stroke in individuals older than 70 years. METHODS: A population-based case-control study of patients admitted to the University Hospital of Ioannina, Epirus, Greece, due to first-ever ischemic/non-embolic stroke from March 1997 to January 2002. All patients were subjected to brain CT and had their serum lipids and biochemical metabolic parameters determined within 24 h from the onset of symptoms. RESULTS: A total of 163 (aged>70 years) consecutive stroke patients and 166 apparently healthy volunteers were studied. An atherogenic lipid profile and metabolic disturbances were more prevalent in the patient group than in stroke-free controls. Multivariate logistic regression analysis identified diabetes mellitus (odds ratio (OR), 1.92; 95% CI, 1.02-3.63), triglycerides (TG) (OR, 1.16; 95% CI, 1.09-1.22), HDL-cholesterol (OR, 0.57; 95% CI, 0.43-0.76), apo A-I (OR, 0.80; 95% CI, 0.70-0.92), lipoprotein(a) [LP(a)] (OR, 1.51; 95% CI, 1.25-1.79), uric acid (OR, 1.30; 95% CI, 1.06-1.59) albumin (OR, 0.38; 95% CI, 0.20-0.70) fibrinogen (OR, 1.10; 95% CI, 1.05-1.13) and the metabolic syndrome (OR 2.48, 95% CI, 1.16-5.29) as significantly associated with ischemic/non-embolic stroke. CONCLUSION: Ischemic non-embolic stroke in the elderly is associated with dyslipidemia and several predictor metabolic factors, which could be substantially modified by lifestyle changes and therapeutic intervention.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.ijcard.2004.01.013-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15749186-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0167527304002104/1-s2.0-S0167527304002104-main.pdf?_tid=609497c979b3c949782c37ad52a3c7bb&acdnat=1333968351_53afea7c25bc015f60213f835a25e0d8-
heal.journalNameInt J Cardiolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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