Paclitaxel and bevacizumab as first line combined treatment in patients with metastatic breast cancer: the Hellenic Cooperative Oncology Group experience with biological marker evaluation

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dc.contributor.authorFountzilas, G.en
dc.contributor.authorKourea, H. P.en
dc.contributor.authorBobos, M.en
dc.contributor.authorTelevantou, D.en
dc.contributor.authorKotoula, V.en
dc.contributor.authorPapadimitriou, C.en
dc.contributor.authorPapazisis, K. T.en
dc.contributor.authorTimotheadou, E.en
dc.contributor.authorEfstratiou, I.en
dc.contributor.authorKoutras, A.en
dc.contributor.authorPentheroudakis, G.en
dc.contributor.authorChristodoulou, C.en
dc.contributor.authorAravantinos, G.en
dc.contributor.authorMiliaras, D.en
dc.contributor.authorPetraki, K.en
dc.contributor.authorPapandreou, C. N.en
dc.contributor.authorPapakostas, P.en
dc.contributor.authorBafaloukos, D.en
dc.contributor.authorRepana, D.en
dc.contributor.authorRazis, E.en
dc.contributor.authorPectasides, D.en
dc.contributor.authorDimopoulos, A. M.en
dc.date.accessioned2015-11-24T19:00:12Z
dc.date.available2015-11-24T19:00:12Z
dc.identifier.issn1791-7530-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19496
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAntibodies, Monoclonal/administration & dosageen
dc.subjectAntibodies, Monoclonal, Humanizeden
dc.subjectAntineoplastic Combined Chemotherapy Protocols/administration &en
dc.subjectdosage/*therapeutic useen
dc.subjectBreast Neoplasms/*drug therapy/metabolism/pathologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectIn Situ Hybridization, Fluorescenceen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Metastasisen
dc.subjectPaclitaxel/administration & dosageen
dc.subjectRetrospective Studiesen
dc.subjectTumor Markers, Biological/*metabolismen
dc.titlePaclitaxel and bevacizumab as first line combined treatment in patients with metastatic breast cancer: the Hellenic Cooperative Oncology Group experience with biological marker evaluationen
heal.abstractBACKGROUND: Randomized studies have shown that bevacizumab combined with taxane-based regimens increases response rates and prolongs progression-free survival (PFS) of patients with metastatic breast cancer (MBC). However predictive or prognostic biological markers that identify the appropriate target population, thus improving the cost-effectiveness ratio of this treatment, are still needed. PATIENTS AND METHODS: Retrospectively, 124 patients with MBC treated either with paclitaxel 90 mg/m(2) weekly x12 plus bevacizumab 10 mug/kg every 2 weeks or 15 mug/kg every 3 weeks (85 patients) or paclitaxel 175 mg/m(2) plus bevacizumab 15 mug/kg every 3 weeks for 6 cycles (36 patients) were identified. Additionally, the prognostic significance of a panel of key biological markers was evaluated centrally by immunohistochemistry (IHC) in 88 evaluable patients. RESULTS: More than two thirds of the patients completed chemotherapy, as planned. The response rate was almost identical (55.3% vs. 55.6%) in the patients treated with weekly or 3-weekly paclitaxel, respectively. After a median follow-up time of 23 months, the median PFS of the study population was 13 months, while median survival had not yet been reached. Common severe adverse events were neutropenia (33%), neuropathy (18.6%) and metabolic disturbances (17.6%). The incidence of hypertension of all grades was 28.1%. High expression of vascular endothelial growth factor (VEGF) receptor 3 (VEGFR3) was associated with clinical response, while high expression of VEGFR1 was associated with poor survival. CONCLUSION: The safety and activity of the combination of bevacizumab with paclitaxel given either weekly or 3-weekly in patients with MBC is confirmed.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21868552-
heal.journalNameAnticancer Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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