Effects of a low-calorie diet associated with weight loss on lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activity in healthy obese women
Φόρτωση...
Ημερομηνία
Συγγραφείς
Tzotzas, T.
Filippatos, T. D.
Triantos, A.
Bruckert, E.
Tselepis, A. D.
Kiortsis, D. N.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Elsevier
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Nutrition Metabolism and Cardiovascular Diseases
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Introduction: Platelet-activating factor acetylhydrolase (PAF-AH or Lp-PLA(2)) is a Ca2+-independent phospholipase A(2) primarily associated in plasma with low density lipoproteins (LDL), especially with small dense LDL (sdLDL) particles. Increased plasma Lp-PLA(2) levels have been associated with increased cardiovascular risk in large clinical trials. Aim: To assess the effects of weight loss on Lp-PLA(2) activity and to examine the association of Lp-PLA(2) activity changes with the alterations of sdLDL, the primary carrier of Lp-PLA(2) in plasma. Methods: Twenty-eight obese, non-diabetic women participated in a weight reduction program. Anthropometric parameters were assessed and parameters of glucose metabolism, lipid profile, Lp-PLA(2) activity, and LDL phenotype (using a 3% polyacrylamide get-tube etectrophoresis method), were determined at baseline and after 4 months of weight loss. Results: A 10% diet-induced weight toss resulted in significant improvement in most parameters of lipid and glucose metabolism. Moreover, Lp-PLA(2) activity was significantly reduced (-10.2%, p < 0.01). Mean LDL particle diameter did not change after the weight toss program. The cholesterol levels of very tow-density lipoprotein (VLDL) and large-buoyant LDL particles were significantly reduced, but neither the cholesterol levels of sdLDL particles nor the % proportion of the sdLDL-cholesterol over the total LDL-cholesterol were changed after the intervention program. Interestingly, the changes in Lp-PLA(2) activity were correlated with the changes of VLDL-chotesterol (r = 0.39, p < 0.05), but not with the changes of anthropometric or other lipid variables. Conclusions: A low-calorie diet associated with weight toss in obese women resulted in the significant reduction of the plasma levels of Lp-PLA(2), the potentially new predictor for incident atherosclerotic disease. (C) 2007 Elsevier B.V. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
lp-pla(2), weight loss, ldl phenotype, very low-density lipoprotein, small dense ldl, activating-factor-acetylhydrolase, coronary-heart-disease, c-reactive protein, middle-aged men, risk-factors, artery-disease, human plasma, insulin-resistance, dense ldl, follow-up
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000259537600004
http://ac.els-cdn.com/S0939475307000804/1-s2.0-S0939475307000804-main.pdf?_tid=e867f6f8bdbee0b9d21750359b55e84a&acdnat=1333112375_f84232640d1f6cdc65053d2f792b575f
http://ac.els-cdn.com/S0939475307000804/1-s2.0-S0939475307000804-main.pdf?_tid=e867f6f8bdbee0b9d21750359b55e84a&acdnat=1333112375_f84232640d1f6cdc65053d2f792b575f
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας