Inflammation and severe demyelination in the peripheral nervous system induced by the intraneural injection of recombinant mouse interleukin-12
Φόρτωση...
Ημερομηνία
Συγγραφείς
Pelidou, S. H.
Deretzi, G.
Zou, L. P.
Quiding, C.
Zhu, J.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Scand J Immunol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Inflammatory cytokines appear to be involved in damage to Schwann cells, myelin and axons, although the exact role of the different cytokines is uncertain. The direct injection model offers a new and simplified way of examining the mechanisms of early inflammation in the peripheral nervous system. The present study was performed to assess the direct effects of interleukin (IL)-12 on rat sciatic nerves injected with recombinant mouse IL-12. Histological and immunohistochemical examination 24 h after injection showed early inflammation as well as demyelination within the injected nerve fibres. By 4 days the inflammatory and demyelinating changes were significantly increased. Seven days after injection, the endoneurium still contained significant numbers of inflammatory cells and the demyelination was even more severe. Control rats injected with sterile phosphate-buffered saline exhibited no such inflammatory and demyelinating response. These changes are similar to those seen in inflammatory and demyelinating disorders of the peripheral nervous system and suggest that IL-12 could be relevant to the pathogenesis of demyelinating diseases such as Guillain-Barre syndrome.
Περιγραφή
Λέξεις-κλειδιά
Animals, CD4 Lymphocyte Count, CD8-Positive T-Lymphocytes/cytology, Demyelinating Diseases/*immunology, Injections, Interleukin-12/administration & dosage/*immunology, Male, Mice, Rats, Rats, Inbred Lew, Recombinant Proteins/administration & dosage/immunology, Sciatic Nerve/drug effects/*immunology/pathology, Time Factors
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/10404050
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής