Increased fatigability of external anal sphincter in inflammatory bowel disease: significance in fecal urgency and incontinence

Απλή σελίδα τεκμηρίου
dc.contributor.authorPapathanasopoulos, A. A.en
dc.contributor.authorKatsanos, K. H.en
dc.contributor.authorTatsioni, A.en
dc.contributor.authorChristodoulou, D. K.en
dc.contributor.authorTsianos, E. V.en
dc.date.accessioned2015-11-24T19:10:50Z
dc.date.available2015-11-24T19:10:50Z
dc.identifier.issn1876-4479-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20873
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAnal Canal/*physiopathology/ultrasonographyen
dc.subjectEndosonographyen
dc.subjectFecal Incontinence/diagnosis/*etiologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectInflammatory Bowel Diseases/*complications/diagnosis/*physiopathologyen
dc.subjectMaleen
dc.subjectManometryen
dc.subjectMiddle Ageden
dc.subject*Muscle Fatigueen
dc.subjectProspective Studiesen
dc.subjectSeverity of Illness Indexen
dc.subjectSigmoidoscopyen
dc.subjectYoung Adulten
dc.titleIncreased fatigability of external anal sphincter in inflammatory bowel disease: significance in fecal urgency and incontinenceen
heal.abstractBACKGROUND AND AIMS: Fatigability of external anal sphincter (EAS) has not been studied in inflammatory bowel disease (IBD) patients. We evaluated EAS fatigability in IBD patients with and without fecal incontinence (FI) and urgency, and correlated fatigability with demographic and clinical factors, and EAS endosonography. METHODS: Fifty-eight consecutive IBD cases and 14 healthy volunteers completed Bristol stool form and a FI severity scale. Groups I, II and III included 27 patients with urgency including 13 with concomitant FI, 31 patients without FI or urgency, and 14 controls, respectively. We performed stationary pull-through manometry with an 8-channel water-perfused catheter. Fatigue rate (FR) was calculated by linear regression during a 20-s anal squeeze, and fatigue rate index (FRI) as the ratio of squeeze pressure increment to FR. EAS thickness and deficits were evaluated with an endoanal 10-MHz probe. Patients underwent sigmoidoscopy. RESULTS: Group I demonstrated a higher Bristol score, more frequent defecations, and more EAS defects compared to group II. Resting, peak squeeze pressures and EAS thickness did not differ between groups. FR was increased in group I versus II, and in group II versus III; FRI was decreased in group I versus II and in group II versus III (p<0.001, adjusting for age and BMI). Gender, oral glucocorticoids, presence of proctitis, perianal disease and EAS defects did not interact with group membership on FR or FRI. CONCLUSIONS: IBD is associated with increased fatigue rate and decreased fatigue rate index. These differences were even more striking in patients with incontinence or urgency.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.crohns.2010.05.002-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21122559-
heal.identifier.secondaryhttp://ac.els-cdn.com/S1873994610000802/1-s2.0-S1873994610000802-main.pdf?_tid=a4c76fc370df1df213ce52c3e63f8d87&acdnat=1334039976_eb18ba3871c7e487a18f4b0b48a79202-
heal.journalNameJ Crohns Colitisen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2010-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Πρωτότυπος φάκελος/πακέτο

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
Papathanasopoulos-2010-Increased fatigabili.pdf
Μέγεθος:
201.83 KB
Μορφότυπο:
Adobe Portable Document Format
Κατεβάστε

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ