Proton magnetic spectroscopic imaging of the child's brain: the response of tumors to treatment

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dc.contributor.authorTzika, A. A.en
dc.contributor.authorZurakowski, D.en
dc.contributor.authorPoussaint, T. Y.en
dc.contributor.authorGoumnerova, L.en
dc.contributor.authorAstrakas, L. G.en
dc.contributor.authorBarnes, P. D.en
dc.contributor.authorAnthony, D. C.en
dc.contributor.authorBillett, A. L.en
dc.contributor.authorTarbell, N. J.en
dc.contributor.authorScott, R. M.en
dc.contributor.authorBlack, P. M.en
dc.date.accessioned2015-11-24T18:55:49Z
dc.date.available2015-11-24T18:55:49Z
dc.identifier.issn0028-3940-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18935
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectBrain/metabolism/pathologyen
dc.subjectBrain Chemistryen
dc.subjectBrain Neoplasms/metabolism/*pathology/therapyen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectInfanten
dc.subjectLogistic Modelsen
dc.subjectMagnetic Resonance Imagingen
dc.subjectMagnetic Resonance Spectroscopy/*diagnostic useen
dc.subjectMaleen
dc.titleProton magnetic spectroscopic imaging of the child's brain: the response of tumors to treatmenten
heal.abstractOur aim was to determine and/or predict response to treatment of brain tumors in children using proton magnetic resonance spectro-scopic imaging (MRSI). We studied 24 patients aged 10 months to 24 years, using MRI and point-resolved spectroscopy (PRESS; TR 2000 TE 65 ms) with volume preselection and phase-encoding in two dimensions on a 1.5 T imager. Multiple logistic regression was used to establish independent predictors of active tumor growth. Biologically vital cell metabolites, such as N-acetyl aspartate and choline-containing compounds (Cho), were significantly different between tumor and control tissues (P < 0.001). The eight brain tumors which responded to radiation or chemotherapy, exhibited lower Cho (P = 0.05), higher total creatine (tCr) (P = 0.02) and lower lactate and lipid (L) (P = 0.04) than 16 tumors which were not treated (except by surgery) or did not respond to treatment. The only significant independent predictor of active tumor growth was tCr (P < 0.01). We suggest that tCr is useful in assessing response of brain tumors to treatment.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/11326567-
heal.journalNameNeuroradiologyen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2001-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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