Immunologic and viral markers in the circulation of anti-HIV negative heroin addicts
| dc.contributor.author | Dalekos, G. N. | en |
| dc.contributor.author | Manoussakis, M. N. | en |
| dc.contributor.author | Zervou, E. | en |
| dc.contributor.author | Tsianos, E. V. | en |
| dc.contributor.author | Moutsopoulos, H. M. | en |
| dc.date.accessioned | 2015-11-24T19:11:48Z | |
| dc.date.available | 2015-11-24T19:11:48Z | |
| dc.identifier.issn | 0014-2972 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20962 | |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Autoantibodies/blood | en |
| dc.subject | Female | en |
| dc.subject | HIV Seropositivity/complications/*immunology/*microbiology | en |
| dc.subject | Hepacivirus/immunology | en |
| dc.subject | Hepatitis Antibodies/blood | en |
| dc.subject | Hepatitis B Antibodies/blood | en |
| dc.subject | Hepatitis B Surface Antigens/blood | en |
| dc.subject | Hepatitis C Antibodies | en |
| dc.subject | Heroin Dependence/complications/*immunology/*microbiology | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Receptors, Interleukin-2/metabolism | en |
| dc.title | Immunologic and viral markers in the circulation of anti-HIV negative heroin addicts | en |
| heal.abstract | To assess the degree of immune system activation associated with addiction or hepatotropic viruses infection, we examined 60 HIV-negative heroin addicts for the presence of hepatitis B virus (HBV) infection markers, hepatitis C virus antibodies (anti-HCV), various auto-antibodies, and serum levels of soluble interleukin-2 receptors (sIL-2R). In addition, 28 anti-HCV positive patients comprising the disease control group, were also examined. Our results demonstrated a high prevalence of anti-HCV antibodies (61.7% and 90% with 1st and 2nd generation ELISA, respectively). Eighty-seven percent (87%) of the addicts positive for anti-HCV by the latter and 92.8% of the disease control patients, were also positive with 2nd generation recombinant immunoblot assay (RIBA-II). In 88.9% of anti-HCV positive addicts, antibody to C22-3 was the predominant (anti-C33c in 81.5%). Antibodies to C33c and C22-3 polypeptides were also more frequent in disease control group (92.8% and 85.7%, respectively). Anti-HCV antibodies were associated with increased transaminases (ALT or AST, P < 0.05), as well as with longer duration of addiction (P < 0.005). HBV infection markers (HBsAg, anti-HBc only and anti-HBs) were also present in the addicts (5%, 28.3% and 26.7%, respectively). Rheumatoid factors (RF) were detected in 36.7%, antinuclear antibodies (ANA) in 11.7%, antibodies (IgG and/or IgM) against cardiolipin (anti-CL) and double stranded DNA (anti-ds DNA) in 20% and 50%, respectively. RF, ANA, anti-CL and anti-dsDNA antibodies were also detected in the disease control group (32.1%, 89.3%, 28.5% and 28.5% respectively).(ABSTRACT TRUNCATED AT 250 WORDS) | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/7684680 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1111/j.1365-2362.1993.tb00765.x/asset/j.1365-2362.1993.tb00765.x.pdf?v=1&t=h0ov8obl&s=9cd73934282a023bbd11ab93be992e7415f57db3 | - |
| heal.journalName | Eur J Clin Invest | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1993 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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