Copper(I)/(II) or silver(I) ions towards 2-mercaptopyrimidine: An exploration of a chemical variability with possible biological implication
Φόρτωση...
Ημερομηνία
Συγγραφείς
Batsala, G. K.
Dokorou, V.
Kourkoumelis, N.
Manos, M. J.
Tasiopoulos, A. J.
Mavromoustakos, T.
Simcic, M.
Golic-Grdadolnik, S.
Hadjikakou, S. K.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Elsevier
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Inorganica Chimica Acta
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Direct reaction of copper(I) chloride with 2-mercaptopyrimidine (pmtH) in the presence of the triphenylphosphine (tpp) in 1: 1: 2 M ratio forms the mixed ligand Cu(I) complex with formula [CuCl(tpp)(2)(pmtH)] (1). The dimeric {[Cu(tpp)(pmt)](2) 0.5(MeOH)} (2) complex was derived from the reaction of 1 with twofold molar amount of sodium hydroxide. However, the reaction of copper(II) sulfate or nitrate with pmtH and tpp in 1: 2: 2 M ratio, unexpectedly results in the formation of the [CuSH(tpp)(2)(pmtH)] (3) complex. Further studies have shown that the [Cu(tpp)(2)(pmt)] (4) complex is formed by reacting copper(II) acetate with pmtH in the presence of tpp in 1: 2: 2 M ratio, while in the absent of tpp, the Cu(CH3COO)(2) or CuSO4 is found to oxidizes pmtH to its corresponding disulfide (pmt)(2). For comparison the mixed ligand silver(I) chloride or nitrate complexes with formula [AgCl(tpp)(2)(pmtH)] (5) or [Ag(NO3)(tpp)(2)(pmtH)] (6) are also synthesized by reacting of the AgCl or AgNO3 with pmtH and tpp in 1: 2: 2 M ratio. The complexes have been characterized by elemental analyses, m. p., vibrational spectroscopy (mid-, far-FT-IR and Raman), H-1 NMR, UV-Vis, ESI-MS, TG-DTA spectroscopic techniques and single crystal X-ray crystallography at ambient conditions. Photolysis of 1-6, was also studied and the results showed formation of triphenylphosphine oxide. The complexes 1-6, were used to study their influence upon the catalytic peroxidation of the linoleic acid by the enzyme lipoxygenase (LOX) experimentally and theoretically. The binding of 1-4 with LOX was also investigated by saturation transfer difference H-1 NMR experiments (STD). (C) 2011 Elsevier B. V. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
bioinorganic chemistry, copper(i) complexes, silver(i) complexes, crystal structures, photolysis, halide coordination-compounds, crystal-structure, molecular-structure, heterocyclic thiones, geometric preferences, disulfide complex, cu(i) complexes, triphenylphosphine, ligand, lipoxygenase
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000300614000020
http://ac.els-cdn.com/S0020169311008346/1-s2.0-S0020169311008346-main.pdf?_tid=102cd6e3f6d68f05f955fa13981037b1&acdnat=1333030090_2ed963750e71fe8095ef1e433f949683
http://ac.els-cdn.com/S0020169311008346/1-s2.0-S0020169311008346-main.pdf?_tid=102cd6e3f6d68f05f955fa13981037b1&acdnat=1333030090_2ed963750e71fe8095ef1e433f949683
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας