Calreticulin Synthetic Peptide Analogs - Antipeptide Antibodies in Autoimmune Rheumatic Diseases
| dc.contributor.author | Routsias, J. G. | en |
| dc.contributor.author | Tzioufas, A. G. | en |
| dc.contributor.author | Sakarellos-Daitsiotis, M. | en |
| dc.contributor.author | Sakarellos, C. | en |
| dc.contributor.author | Moutsopoulos, H. M. | en |
| dc.date.accessioned | 2015-11-24T16:53:22Z | |
| dc.date.available | 2015-11-24T16:53:22Z | |
| dc.identifier.issn | 0009-9104 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/10007 | |
| dc.rights | Default Licence | - |
| dc.subject | calreticulin | en |
| dc.subject | ro/ssa | en |
| dc.subject | autoimmune rheumatic diseases | en |
| dc.subject | synthetic peptides | en |
| dc.subject | calcium-binding protein | en |
| dc.subject | ro/ss-a autoantigen | en |
| dc.subject | ro ribonucleoprotein | en |
| dc.subject | lupus-erythematosus | en |
| dc.subject | molecular-cloning | en |
| dc.subject | particle | en |
| dc.subject | sequence | en |
| dc.subject | heterogeneity | en |
| dc.subject | calregulin | en |
| dc.subject | component | en |
| dc.title | Calreticulin Synthetic Peptide Analogs - Antipeptide Antibodies in Autoimmune Rheumatic Diseases | en |
| heal.abstract | Autoantibodies in sera from patients with systemic lupus erythematosus (SLE) and onchocerciasis recognize calreticulin (CaR), a calcium-binding protein, as antigen. In this study we present the immunological properties of two synthetic peptides prepared to correspond to the 1-24 and 7-24 amino acid sequence of CaR. In contrast to information previously reported for the recombinant protein, the CaR-peptide analogues appeared immunoreactive to anti-Ro/SSA autoimmune sera. Human sera from patients with SLE, Sjogren's syndrome (SS), rheumatoid arthritis (RA), as well as mixed connective tissue disease (MCTD), demonstrated a positive autoimmune response (binding of antibodies), to the CaR-peptide analogues. These findings suggest that anti-calreticulin autoantibodies are not restricted to any disease specificity. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | <Go to ISI>://A1993KP26700016 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1111/j.1365-2249.1993.tb05921.x/asset/j.1365-2249.1993.tb05921.x.pdf?v=1&t=h0e0qi0o&s=25c3969a70c18d624a2d8c3f16a35c94a6eb5d76 | - |
| heal.journalName | Clin Exp Immunol | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1993 | - |
| heal.publisher | Blackwell | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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