Emerging options in the treatment of dyslipidemias: a bright future?
| dc.contributor.author | Florentin, M. | en |
| dc.contributor.author | Liberopoulos, E. N. | en |
| dc.contributor.author | Mikhailidis, D. P. | en |
| dc.contributor.author | Elisaf, M. S. | en |
| dc.date.accessioned | 2015-11-24T19:19:53Z | |
| dc.date.available | 2015-11-24T19:19:53Z | |
| dc.identifier.issn | 1744-7623 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21994 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Anticholesteremic Agents/adverse effects/*therapeutic use | en |
| dc.subject | Cholesterol, HDL/blood | en |
| dc.subject | Dyslipidemias/blood/*drug therapy | en |
| dc.subject | Humans | en |
| dc.title | Emerging options in the treatment of dyslipidemias: a bright future? | en |
| heal.abstract | INTRODUCTION: Hypercholesterolemia is a major risk factor for cardiovascular disease (CVD). Low-density lipoprotein cholesterol (LDL-C) reduction has been demonstrated to decrease CVD-related morbidity and mortality. However, several patients do not reach LDL-C target levels with the currently available lipid lowering agents, particularly statins. Lipid and non-lipid parameters other than LDL-C may account for the residual CVD risk after adequate LDL-C lowering with statins. AREAS COVERED: This review focuses on the efficacy and safety of emerging drugs aiming at high-density lipoprotein cholesterol (HDL-C) elevation (i.e., recombinant or plasma-derived wild-type apolipoprotein (apo) A-I, apo A-I mimetic peptides, reconstituted mutant HDL, partially delipidated HDL and cholesterol ester transfer protein inhibitors), microsomal triglyceride transfer protein inhibitors and antisense oligonucleotides. EXPERT OPINION: Several lipid modifying agents in development may potently reduce the residual CVD risk. Ongoing and future studies with clinical outcomes will clarify their efficacy in clinical practice. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1517/14728214.2011.554395 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/21323473 | - |
| heal.identifier.secondary | http://informahealthcare.com/doi/abs/10.1517/14728214.2011.554395 | - |
| heal.journalName | Expert Opin Emerg Drugs | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2011 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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