Molecular properties of HLA-DQ alleles conferring susceptibility to or protection from insulin-dependent diabetes mellitus: keys to the fate of islet beta-cells
| dc.contributor.author | Moustakas, A. K. | en |
| dc.contributor.author | Papadopoulos, G. K. | en |
| dc.date.accessioned | 2015-11-24T19:03:58Z | |
| dc.date.available | 2015-11-24T19:03:58Z | |
| dc.identifier.issn | 0148-7299 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19950 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Diabetes Mellitus, Type 1/*genetics/immunology/physiopathology | en |
| dc.subject | HLA-DQ Antigens/chemistry/*genetics/physiology | en |
| dc.subject | HLA-DR Antigens/chemistry/*genetics | en |
| dc.subject | Humans | en |
| dc.subject | Islets of Langerhans/immunology | en |
| dc.subject | Protein Structure, Tertiary | en |
| dc.title | Molecular properties of HLA-DQ alleles conferring susceptibility to or protection from insulin-dependent diabetes mellitus: keys to the fate of islet beta-cells | en |
| heal.abstract | The major histocompatibility complex Class II alleles, HLA-DQ, and the related HLA-DR, are the chief genetic elements of human type 1 diabetes. These genes code for polymorphic heterodimeric proteins, whose chief function is to trap peptide antigens in the endosome and present them on the surface of antigen-presenting cells (dendritic cells, B lymphocytes, monocytes/macrophages) to CD4(+) T helper cells. A systematic investigation of the molecular properties of HLA-DQ alleles linked to susceptibility or resistance to type 1 diabetes has shown that these properties segregate along lines of susceptibility or resistance. A correlation of these features with the function of each particular segment of the HLA-DQ molecule yields interesting insights into the possible pathways leading to type 1 diabetes. There remain, however, areas to be clarified, including mechanisms by which dominant protection is conferred by certain alleles, the interplay between HLA-DQ and the related locus HLA-DR, that also shows autoantigen-specific reactivity, and the cross-Class help delivered to CD8(+) T cells, the final effectors in pancreatic beta-cell destruction. Clarification of these issues may lead to ways to prevent diabetes in predisposed individuals already exhibiting the genetic and immunological characteristics, and perhaps a cure in those with the disease, by means of transplantation, and measures for prevention of disease recurrence. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1002/ajmg.10342 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/12116175 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1002/ajmg.10342/asset/10342_ftp.pdf?v=1&t=h0uss8u0&s=d7bffddadc7acef2d9238b495f06264fc7ad5d78 | - |
| heal.journalName | Am J Med Genet | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2002 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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