Association of the A1330V and V667M polymorphisms of LRP5 with bone mineral density in Greek peri- and postmenopausal women

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dc.contributor.authorMarkatseli, A. E.en
dc.contributor.authorHatzi, E.en
dc.contributor.authorBouba, I.en
dc.contributor.authorGeorgiou, I.en
dc.contributor.authorChalla, A.en
dc.contributor.authorTigas, S.en
dc.contributor.authorTsatsoulis, A.en
dc.date.accessioned2015-11-24T19:34:37Z
dc.date.available2015-11-24T19:34:37Z
dc.identifier.issn1873-4111-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23637
dc.rightsDefault Licence-
dc.subjectAllelesen
dc.subjectBiological Markers/blood/metabolismen
dc.subjectBody Mass Indexen
dc.subjectBone Density/*geneticsen
dc.subjectBone and Bones/*metabolismen
dc.subjectFemaleen
dc.subject*Genotypeen
dc.subjectGreeceen
dc.subjectHaplotypesen
dc.subjectHumansen
dc.subjectLinkage Disequilibriumen
dc.subjectLow Density Lipoprotein Receptor-Related Protein-5/*geneticsen
dc.subjectMiddle Ageden
dc.subjectOsteoprotegerin/blood/*geneticsen
dc.subjectPerimenopause/geneticsen
dc.subject*Polymorphism, Single Nucleotideen
dc.subjectPostmenopause/geneticsen
dc.subjectReal-Time Polymerase Chain Reactionen
dc.subjectReceptor Activator of Nuclear Factor-kappa B/blood/*geneticsen
dc.subjectRisk Factorsen
dc.subjectSignal Transduction/geneticsen
dc.subjectWnt Proteins/metabolismen
dc.titleAssociation of the A1330V and V667M polymorphisms of LRP5 with bone mineral density in Greek peri- and postmenopausal womenen
heal.abstractWnt signaling through low-density lipoprotein receptor-related protein 5 (LRP5) is an important determinant of bone mass regulation. OBJECTIVE: To explore the influence of two LRP5 single nucleotide polymorphisms (SNPs) A1330V and V667M on bone mineral density (BMD) and serum levels of osteoprotegerin (OPG), receptor activator of nuclear factor-kappaB ligand (RANKL) and bone metabolic markers in a Greek female population. STUDY DESIGN: Two hundred and nine postmenopausal and twelve perimenopausal women aged 40-63 years were enrolled. All participants underwent spinal BMD evaluation. Genotyping of A1330V and V667M polymorphisms was performed by real-time polymerase chain reaction. Levels of OPG, soluble RANKL (sRANKL) and bone metabolic markers were measured. RESULTS: As regards A1330V SNP, women carrying CT/TT genotypes had lower spinal BMD than women with CC (p<0.0001). Regarding V667M SNP, spinal BMD was lower in women with GA/AA than in women with GG genotypes (p<0.0001). These differences remained significant after adjustment for age, years since menopause and body mass index. The A1330V and V667M polymorphisms were in strong linkage disequilibrium. A significant interaction between A1330V and V667M SNPs on spinal BMD was revealed. The haplotype with both risk alleles of the two SNPs (AT) conferred more risk for low BMD than the haplotypes with one risk allele (GT or AC) or the haplotype-reference (GC) (p=0.046, p=0.045, and p=0.010, respectively). No effect was observed on circulating OPG, sRANKL levels and bone metabolic markers. CONCLUSIONS: These findings demonstrate that the A1330V and V667M polymorphisms are associated with low BMD in peri- and postmenopausal Greek women.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.maturitas.2011.07.016-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21840657-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0378512211002507/1-s2.0-S0378512211002507-main.pdf?_tid=5df208d1782a2616acda1b58f24c2e11&acdnat=1333347466_6183519b6bbea64652b75b643c54b9da-
heal.journalNameMaturitasen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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