Effect of gonadotrophin-releasing hormone agonist treatment on growth hormone secretion in women with polycystic ovarian syndrome
| dc.contributor.author | Kaltsas, T. | en |
| dc.contributor.author | Pontikides, N. | en |
| dc.contributor.author | Krassas, G. E. | en |
| dc.contributor.author | Seferiadis, K. | en |
| dc.contributor.author | Lolis, D. | en |
| dc.contributor.author | Messinis, I. E. | en |
| dc.date.accessioned | 2015-11-24T19:22:55Z | |
| dc.date.available | 2015-11-24T19:22:55Z | |
| dc.identifier.issn | 0268-1161 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22206 | |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Case-Control Studies | en |
| dc.subject | Female | en |
| dc.subject | Gonadotropins, Pituitary/*therapeutic use | en |
| dc.subject | Hormones/secretion | en |
| dc.subject | Human Growth Hormone/*secretion | en |
| dc.subject | Humans | en |
| dc.subject | Ovulation Induction/*methods | en |
| dc.subject | Polycystic Ovary Syndrome/*drug therapy | en |
| dc.subject | Receptors, LHRH/*agonists | en |
| dc.title | Effect of gonadotrophin-releasing hormone agonist treatment on growth hormone secretion in women with polycystic ovarian syndrome | en |
| heal.abstract | The suppression of the pituitary-gonadal axis by the administration of gonadotrophin-releasing hormone agonists (GnRH-a) is used occasionally as an adjunct therapy with gonadotrophins for ovulation induction in women with polycystic ovarian syndrome (PCOS). A number of recent clinical studies have suggested that women with polycystic ovaries (PCO) may have disturbances of normal growth hormone (GH) kinetics and alterations in the GH/insulin-like growth factor (IGF)-I system. The purpose of this study was to determine the effect of GnRH-a administration on GH-releasing hormone (GHRH)-stimulated GH release in women with PCOS. Eight women with PCO and six control women were studied before and after 2 months of treatment with the long acting GnRH-a triptoreline (3.75 mg monthly injections). GHRH was given as a single i.v. injection and blood samples for GH measurements were obtained at -15, 0, 30, 60, 90 and 120 min. The GH responses were expressed as the area under the curve (AUC) or the differences from the basal value (delta(max)). The GH response to GHRH (mean +/- SEM) was lower in women with PCO (AUC 114.9 +/- 43.1 versus 206.2 +/- 28.7 ng/ml/120 min, P < 0.05 and delta(max) 31.6 +/- 8.2 versus 49.4 +/- 5.8 ng/ml, P < 0.05). After treatment with the GnRH-a, the GH response to GHRH was significantly smaller than before treatment in both groups (PCO AUC 34.6 +/- 9.0 ng/ml/120 min and delta(max) 12.4 +/- 3.1 ng/ml; controls AUC 148.8 +/- 28.4 ng/ml/120 min and delta(max) 31.2 +/- 6.1 ng/ml), but the PCO group had a significantly smaller response. These data demonstrate that women with PCO have a reduced GH response to GHRH compared with normal controls and that GnRH-a administration causes a further GH reduction in both groups. Women with PCO have a greater suppression of GH response to GHRH during treatment with GnRH-a. This suggests that a different level of sensitivity in the somatotrophic axis exists in PCOS. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/9512222 | - |
| heal.identifier.secondary | http://humrep.oxfordjournals.org/content/13/1/22.full.pdf | - |
| heal.journalName | Hum Reprod | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1998 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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