The Challenging Evaluation of Patients with Severe Psoriasis for Latent Tuberculosis: An Important Indication for IGRA

dc.contributor.authorKatsenos, S.en
dc.contributor.authorNikolopoulou, M.en
dc.contributor.authorTsiouri, G.en
dc.contributor.authorBassukas, I. D.en
dc.contributor.authorConstantopoulos, S. H.en
dc.date.accessioned2015-11-24T19:42:20Z
dc.date.available2015-11-24T19:42:20Z
dc.identifier.issn1874-3064-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24624
dc.rightsDefault Licence-
dc.titleThe Challenging Evaluation of Patients with Severe Psoriasis for Latent Tuberculosis: An Important Indication for IGRAen
heal.abstractIt is well-established that tumour necrosis factor (TNF)-alpha-antagonist regimens are advisable for the control of moderate to severe psoriasis; however the application of these agents is associated with increased risk of TB reactivation. Screening for latent tuberculosis infection (LTBI) is indispensable prior to treatment inception in order to diminish the risk of active TB. Although tuberculin skin test (TST) still represents a useful tool for LTBI detection, it is difficult to be performed and read in patients with extensive psoriatic lesions. In this paper, we report the case of a 65-year-old male with severe psoriasis, who was evaluated by an interferon-gamma release assay (IGRA) for LTBI diagnosis prior to anti-TNF-alpha therapy. Furthermore, the physiological aspects of interferon-gamma release assays are discussed emphasizing the value of these novel immunodiagnostic tests (IGRAs) for presumable LTBI in all patients with extensive skin disorders.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.2174/1874306401105010059-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21754976-
heal.journalNameOpen Respir Med Jen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Πρωτότυπος φάκελος/πακέτο

Προβολή: 1 - 1 of 1
Φόρτωση...
Μικρογραφία εικόνας
Ονομα:
Constantopoulos-2011-the challenging evaluation.pdf
Μέγεθος:
257.32 KB
Μορφότυπο:
Adobe Portable Document Format

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Φόρτωση...
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή: