Pre-decondensed sperm head injections into female pronuclei result in chromosomal mingling, zygotic cleavage, and adequate embryonic and fetal development up to delivery of healthy offspring: a novel method of assisted syngamy
Φόρτωση...
Ημερομηνία
Συγγραφείς
Sofikitis, N.
Baltogiannis, D.
Takenaka, M.
Tsoukanelis, K.
Tsambalas, S.
Yamamoto, Y.
Kanakas, N.
Giannakis, D.
Loutradis, D.
Adonakis, G.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Andrologia
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Investigation of the developmental potential post-injection of a pre-decondensed or non-pre-decondensed sperm head into the female pronucleus of a pre-activated oocyte. Rat pre-activated oocytes were treated with intrapronuclear pre-decondensed sperm head injections (IPSHI) (n = 133) or intrapronuclear non-pre-decondensed sperm head injections (INPSHI) (n = 138). All injected oocytes were transferred to pseudopregnant female recipients. Rat IPSHI techniques resulted in the delivery of five healthy offspring. Rat INPSHI techniques did not result in any pregnancies. Rat IPSHI techniques can result in delivery of healthy offspring. Successful performance of human IPSHI techniques might serve as a novel method to manage cases of intracytoplasmic sperm injection failure due to lack of development of male pronucleus or due to failure in pronuclei fusion.
Περιγραφή
Λέξεις-κλειδιά
Animals, Cell Nucleus, Chromosomes/*physiology, *Cleavage Stage, Ovum, *Embryonic Development, Female, *Fetal Development, Male, *Microinjections, *Oocytes, Rats, Rats, Wistar, *Reproductive Techniques, Assisted, *Sperm Head
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/15458548
http://onlinelibrary.wiley.com/store/10.1111/j.1439-0272.2004.00622.x/asset/j.1439-0272.2004.00622.x.pdf?v=1&t=h0p8bql0&s=78cb322d65930cc82ab5a5580eeff9b041460083
http://onlinelibrary.wiley.com/store/10.1111/j.1439-0272.2004.00622.x/asset/j.1439-0272.2004.00622.x.pdf?v=1&t=h0p8bql0&s=78cb322d65930cc82ab5a5580eeff9b041460083
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής