Harmonic voiding urosonography with a second-generation contrast agent for the diagnosis of vesicoureteral reflux

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dc.contributor.authorPapadopoulou, F.en
dc.contributor.authorAnthopoulou, A.en
dc.contributor.authorSiomou, E.en
dc.contributor.authorEfremidis, S.en
dc.contributor.authorTsamboulas, C.en
dc.contributor.authorDarge, K.en
dc.date.accessioned2015-11-24T19:14:24Z
dc.date.available2015-11-24T19:14:24Z
dc.identifier.issn0301-0449-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21304
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectChi-Square Distributionen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectContrast Mediaen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectInfanten
dc.subjectInfant, Newbornen
dc.subjectMaleen
dc.subjectPhospholipids/*diagnostic useen
dc.subjectProspective Studiesen
dc.subjectSensitivity and Specificityen
dc.subjectSulfur Hexafluoride/*diagnostic useen
dc.subjectUrinationen
dc.subjectVesico-Ureteral Reflux/radiography/*ultrasonographyen
dc.titleHarmonic voiding urosonography with a second-generation contrast agent for the diagnosis of vesicoureteral refluxen
heal.abstractBACKGROUND: Voiding urosonography with harmonic imaging (VUS HI) has been introduced as a sensitive and radiation-free imaging method for the diagnosis and follow-up of vesicoureteral reflux (VUR) in children. OBJECTIVE: The purpose of this study was to evaluate the sensitivity of VUS HI using a second-generation US contrast agent compared to standard voiding cystourethrography (VCUG). MATERIALS AND METHODS: A total of 228 children with 463 kidney-ureter units (KUUs) underwent two cycles of VUS HI and two cycles of VCUG at the same session. VUS HI was performed after intravesical administration of 1 ml of a second-generation US contrast agent (sulphur-hexafluoride gas microbubbles, SonoVue, Bracco, Italy). For statistical analysis we used McNemar's test, Student's t-test and k coefficient tests. RESULTS: VUR was shown in 161/463 (34.7%) KUUs, 57 by both methods, 90 only by VUS, and 14 only by VCUG. Concordance in findings regarding the presence or absence of VUR was found in 359/463 (77.5%) KUUs (k=0.40). The difference in the detection rate of reflux between the two methods was significant (P<0.01). More importantly, reflux missed by VCUG was of higher grade (2 grade I, 65 grade II, 19 grade III, 4 grade IV) than that missed by VUS (8 grade I, 5 grade II, 1 grade III). CONCLUSION: VUS HI and a second-generation contrast agent improved the identification of reflux in children. Our data reveal a higher sensitivity of the method compared to VCUG. Thus it can be used as an alternative radiation-free imaging method.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1007/s00247-008-1080-x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19096835-
heal.identifier.secondaryhttp://www.springerlink.com/content/3051235q71741700/fulltext.pdf-
heal.journalNamePediatric Radiologyen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2009-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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