An electron microscopic and biochemical study of the effects of propranolol on the glycogen autophagy in newborn rat hepatocytes

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dc.contributor.authorKotoulas, O. B.en
dc.contributor.authorKalamidas, S. A.en
dc.contributor.authorMiles, P.en
dc.contributor.authorHann, A. C.en
dc.date.accessioned2015-11-24T19:36:37Z
dc.date.available2015-11-24T19:36:37Z
dc.identifier.issn0213-3911-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23912
dc.rightsDefault Licence-
dc.subjectAdenosine Triphosphatases/metabolismen
dc.subjectAdrenergic beta-Antagonists/pharmacologyen
dc.subjectAnimalsen
dc.subjectAnimals, Newbornen
dc.subjectAutophagyen
dc.subjectBiochemical Phenomenaen
dc.subjectBiochemistryen
dc.subjectCells, Cultureden
dc.subjectCyclic AMP/metabolismen
dc.subjectCyclic AMP-Dependent Protein Kinases/metabolismen
dc.subjectGlycogen/*metabolismen
dc.subjectHepatocytes/*metabolismen
dc.subjectImmunohistochemistryen
dc.subjectLiver/metabolismen
dc.subjectMicroscopy, Electronen
dc.subjectPhosphoric Monoester Hydrolases/metabolismen
dc.subjectPropranolol/*pharmacologyen
dc.subjectRatsen
dc.subjectTime Factorsen
dc.subjectalpha-Glucosidases/metabolismen
dc.titleAn electron microscopic and biochemical study of the effects of propranolol on the glycogen autophagy in newborn rat hepatocytesen
heal.abstractThe effects of propranolol on the glycogen autophagy in newborn rat hepatocytes were studied by using biochemical determinations, electron microscopy and morphometric analysis. Propranolol lowered the liver cyclic AMP and cyclic AMP-dependent protein kinase activity. It also decreased the formyl-methionyl-leucyl-phenylalanine (FMLP)-inhibitable Ca2+-ATPase activity including lysosomal calcium uptake pump. The normal postnatal increase in the volume of autophagic vacuoles and the activity of acid glycogen-hydrolyzing alpha glucosidase were inhibited. Also, the degradation of glycogen inside the autophagic vacuoles was apparently inhibited. The activity of acid mannose 6-phosphatase was increased. These findings indicate that propranolol influences several steps in the sequence of events leading to the breakdown of glycogen in the autophagic vacuoles of newborn rat hepatocytes. This supports our previous studies suggesting that cyclic AMP regulates glycogen autophagy.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12792893-
heal.journalNameHistol Histopatholen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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