Circulating antibodies to prothymosin alpha in systemic lupus erythematosus
| dc.contributor.author | Vlachoyiannopoulos, P. G. | en |
| dc.contributor.author | Frillingos, S. | en |
| dc.contributor.author | Tzioufas, A. G. | en |
| dc.contributor.author | Seferiadis, K. | en |
| dc.contributor.author | Moutsopoulos, H. M. | en |
| dc.contributor.author | Tsolas, O. | en |
| dc.date.accessioned | 2015-11-24T19:30:31Z | |
| dc.date.available | 2015-11-24T19:30:31Z | |
| dc.identifier.issn | 0090-1229 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23114 | |
| dc.rights | Default Licence | - |
| dc.subject | Antibodies, Antinuclear/immunology | en |
| dc.subject | Autoantibodies/*immunology | en |
| dc.subject | Autoantigens/*immunology | en |
| dc.subject | Enzyme-Linked Immunosorbent Assay | en |
| dc.subject | Humans | en |
| dc.subject | Immunoglobulin Idiotypes/analysis | en |
| dc.subject | Lupus Erythematosus, Systemic/*immunology | en |
| dc.subject | Protein Precursors/*immunology | en |
| dc.subject | Thymosin/immunology | en |
| dc.title | Circulating antibodies to prothymosin alpha in systemic lupus erythematosus | en |
| heal.abstract | Autoantibodies to prothymosin alpha, an immunoactive protein that exists in a large variety of mammalian tissues, were found to be present in patients with systemic lupus erythematosus (SLE) by a new, sensitive, and specific anti-prothymosin alpha ELISA. The antigen was prothymosin alpha, purified by high-pressure liquid chromatography from goat spleen extracts. Sera from 44 SLE patients and 276 healthy individuals were screened for the presence of anti-prothymosin alpha activity; 18% of SLE sera were found to be positive, compared with 1.8% of control sera. This anti-prothymosin alpha activity appears to be idiotypically distinct from either anti-thymosin alpha 1 activity or anti-dsDNA activity, as demonstrated by inhibition experiments. Significant positive correlation exists between anti-prothymosin alpha and anti-dsDNA activities of SLE sera (r = +0.596, n = 36, P less than 0.001), while no correlation was observed with the clinical activity (X2 = 1.239, 0.1 less than P less than 0.5) or with complement levels C3 and C4. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/2791337 | - |
| heal.journalName | Clin Immunol Immunopathol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1989 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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