Organotin-drug interactions. Organotin adducts of lornoxicam, synthesis and characterisation of the first complexes of lornoxicam
| dc.contributor.author | Galani, A. | en |
| dc.contributor.author | Demertzis, M. A. | en |
| dc.contributor.author | Kubicki, M. | en |
| dc.contributor.author | Kovala-Demertzi, D. | en |
| dc.date.accessioned | 2015-11-24T16:43:39Z | |
| dc.date.available | 2015-11-24T16:43:39Z | |
| dc.identifier.issn | 1434-1948 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/8723 | |
| dc.rights | Default Licence | - |
| dc.subject | antitumour agents | en |
| dc.subject | tin | en |
| dc.subject | supramolecular chemistry | en |
| dc.subject | drug delivery | en |
| dc.subject | crystal-structure | en |
| dc.subject | diorganotin derivatives | en |
| dc.subject | molecular-structure | en |
| dc.subject | mefenamic-acid | en |
| dc.subject | hydrogen-bond | en |
| dc.subject | tenoxicam | en |
| dc.subject | contacts | en |
| dc.title | Organotin-drug interactions. Organotin adducts of lornoxicam, synthesis and characterisation of the first complexes of lornoxicam | en |
| heal.abstract | The synthesis and spectral characterisation of novel organotin complexes [SnMe2(lorn)] (1) and [SnBu2(lorn)] (2) of the potent and widely used anti-inflammatory drug lornoxicam, H(2)lorn, are reported. Crystal structure determinations of complexes1 and 2 showed that the ligand is doubly deprotonated at the oxygen and amide nitrogen atoms and is coordinated to the SnR2 fragment via four- and six-membered chelate rings. The monomers of 1 are linked through intermolecular hydrogen bonds of C-H--O type and through C-H-pi intermolecular interactions. There are two similar molecules in the asymmetric unit of 2. The dimers of 2 are arranged in polymers with a stacking of alternate parallel chains and are linked through intermolecular hydrogen bonds of C-H--O type, and through C-H-n intermolecular interactions. An extended network of Sn-O-Sn, C-H--O and C-H--pi contacts lead to aggregation and a supramolecular assembly. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003). | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | DOI 10.1002/ejic.200200514 | - |
| heal.identifier.secondary | <Go to ISI>://000182964000014 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1002/ejic.200200514/asset/1761_ftp.pdf?v=1&t=h0duo4uv&s=9521589e352d17a98fde9d5fc7e38af23957c1fe | - |
| heal.journalName | European Journal of Inorganic Chemistry | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2003 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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