Serum lipoprotein(a) levels and apolipoprotein(a) isoform size and risk for first-ever acute ischaemic nonembolic stroke in elderly individuals

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dc.contributor.authorMilionis, H. J.en
dc.contributor.authorFilippatos, T. D.en
dc.contributor.authorLoukas, T.en
dc.contributor.authorBairaktari, E. T.en
dc.contributor.authorTselepis, A. D.en
dc.contributor.authorElisaf, M. S.en
dc.date.accessioned2015-11-24T16:47:04Z
dc.date.available2015-11-24T16:47:04Z
dc.identifier.issn0021-9150-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9138
dc.rightsDefault Licence-
dc.subjectelderlyen
dc.subjectischaemic strokeen
dc.subjectlipoprotein(a)en
dc.subjectapolipoprotein(a)en
dc.subjectisoform sizeen
dc.subjectcoronary-heart-diseaseen
dc.subjectplasma lipoprotein(a)en
dc.subjectlp(a) concentrationsen
dc.subjectcerebral infarctionen
dc.subjectvascular-diseaseen
dc.subjectcontrolled trialen
dc.subjectmenen
dc.subjectcholesterolen
dc.subjectpravastatinen
dc.subjectpopulationen
dc.titleSerum lipoprotein(a) levels and apolipoprotein(a) isoform size and risk for first-ever acute ischaemic nonembolic stroke in elderly individualsen
heal.abstractIn a population-based case-control study, we investigated the association of acute ischaemic stroke with lipoprotein(a) (Lp(a)) levels and apolipoprotein (Apo) (a) isoform size in subjects aged older than 70 years. A total of 163 patients with a first-ever-in-a-lifetime acute ischaemic/nonembolic stroke and 166 controls were included. Compared to controls, stroke patients exhibited higher Lp(a) concentrations (median value, 12.2 mg/dl versus 6.4 mg/dl, p < 0.001) and a higher frequency of small Apo(a) isoforms (44.2% versus 29.5%, p < 0.01). Multivariate logistic regression analysis showed a significant association 4 acute ischaemic stroke with Lp(a) levels [adjusted odds ratio (OR), 1.37, 95% CI (1.12-1.67); p = 0.002], and small Apo(a) isoform size [OR, 1.74 (1.10-3.03);p = 0.04]. Compared to subjects with Lp(a) levels in the lowest quintile, those within the highest quintile had a 3.2-times adjusted risk to suffer an acute ischaernic/nonembolic stroke (1.60-6.62, 95% CI; p < 0.001). Furthermore, analysis of interaction between lipid variables revealed that in the presence of elevated Lp(a) levels the inverse relationship between HDL-cholesterol levels and ischaemic stroke was negated [OR, 1.01 (1.00-1.03); p = 0.015]. Our study suggests that determination of Lp(a) levels and Apo(a) isoform size may be important in identifying elderly individuals at risk of ischaemic stroke independently of other risk factors and concurrent metabolic derangements. (c) 2005 Elsevier Ireland Ltd. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.atherosclerosis.2005.08.036-
heal.identifier.secondary<Go to ISI>://000239073400021-
heal.identifier.secondaryhttp://ac.els-cdn.com/S002191500500585X/1-s2.0-S002191500500585X-main.pdf?_tid=c4a36ba1664eea34da8cf8f13ce9d03f&acdnat=1333111610_20e761718d313aabc5dfa3be0edcae49-
heal.journalNameAtherosclerosisen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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