Synthesis of a novel triphenyltin(IV) derivative of 2-mercaptonicotinic acid with strong cytotoxicity in vitro
| dc.contributor.author | Xanthopoulou, M. N. | en |
| dc.contributor.author | Hadjikakou, S. K. | en |
| dc.contributor.author | Hadjiliadis, N. | en |
| dc.contributor.author | SchΓΌrmann, M. | en |
| dc.contributor.author | Jurkschat, K. | en |
| dc.contributor.author | Binolis, J. | en |
| dc.contributor.author | Karkabounas, S. | en |
| dc.contributor.author | Charalabopoulos, K. | en |
| dc.date.accessioned | 2015-11-24T16:49:14Z | |
| dc.date.available | 2015-11-24T16:49:14Z | |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9451 | |
| dc.rights | Default Licence | - |
| dc.subject | triphenyltin(IV) compound, S ligands-heterocyclic thioamides, mercaptonicotinic acid, crystal structures | en |
| dc.title | Synthesis of a novel triphenyltin(IV) derivative of 2-mercaptonicotinic acid with strong cytotoxicity in vitro | en |
| heal.abstract | A novel triphenyltin(IV) derivative of 2-mercaptonicotinic acid (Hzmna) of formula {[(C6Hs)3Sn]E(mna)"™[(CH3)2CO]} (1) has been synthesized and characterized by elemental analysis and 13C-NMR, and FT-IR spectroscopic techniques. The crystal structure of complex (1) has been determined by single crystal X-ray diffraction analysis at 173(1) K. Compound (1) contains two triphenyltin moieties linked by a doubly de-protonated 2,mercaptonicotinic acid (HEmna). It is an example of a pentacoordinated Ph3SnXY system with an axial-equatorial arrangement of the phenyl groups at Sn(1). Compound (1), exhibits potent, in vitro, cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, polycyclic aromatic hydrocarbons (PAH, benzo[a]pyrene) carcinogenesis. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.journalName | Bioinorganic Chemistry & Applications | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2003 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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