HLA-DR expression by labial minor salivary gland tissues in Sjogren's syndrome

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dc.contributor.authorMoutsopoulos, H. M.en
dc.contributor.authorHooks, J. J.en
dc.contributor.authorChan, C. C.en
dc.contributor.authorDalavanga, Y. A.en
dc.contributor.authorSkopouli, F. N.en
dc.contributor.authorDetrick, B.en
dc.date.accessioned2015-11-24T19:13:19Z
dc.date.available2015-11-24T19:13:19Z
dc.identifier.issn0003-4967-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21177
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectFemaleen
dc.subjectHLA-DR Antigensen
dc.subjectHistocompatibility Antigens Class II/*analysisen
dc.subjectHumansen
dc.subjectImmunoenzyme Techniquesen
dc.subjectLymphocytes/immunologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectSalivary Glands/*immunologyen
dc.subjectSalivary Glands, Minor/*immunology/pathologyen
dc.subjectSjogren's Syndrome/*immunology/pathologyen
dc.titleHLA-DR expression by labial minor salivary gland tissues in Sjogren's syndromeen
heal.abstractMinor salivary gland biopsy specimens from patients with Sjogren's syndrome (primary and secondary) and from normal controls were examined with the four step biotin-avidin-immunoperoxidase assay. The composition of the infiltrating cells was similar in patients with both primary and secondary Sjogren's syndrome, consisting primarily of T lymphocytes with predominance of T helper/inducer cells. B lymphocytes (Leu-14) were approximately 20-35% of the infiltrating lymphocytes, while only a few OKM1 (monocytes/macrophages) cells and Leu-7+ (natural killer; NK) cells were observed. The majority of infiltrating lymphocytes expressed HLA-DR antigens. In the biopsy specimens of the controls there were no infiltrates; the scattered lymphocytes, however, were also predominantly T lymphocytes. Finally, the glandular epithelial cells (ducts and acini) were inappropriately expressing HLA-DR antigens, in contrast with controls where minimal HLA-DR expression was found.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/3527087-
heal.identifier.secondaryhttp://ard.bmj.com/content/45/8/677.full.pdf-
heal.journalNameAnn Rheum Disen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1986-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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