Angiotensin II type 2 receptor gene polymorphism in Caucasian children with a wide spectrum of congenital anomalies of the kidney and urinary tract

Απλή σελίδα τεκμηρίου
dc.contributor.authorSiomou, E.en
dc.contributor.authorBouba, I.en
dc.contributor.authorKollios, K. D.en
dc.contributor.authorPapadopoulou, F.en
dc.contributor.authorSyrrou, M.en
dc.contributor.authorGeorgiou, I.en
dc.contributor.authorSiamopoulou, A.en
dc.date.accessioned2015-11-24T19:36:13Z
dc.date.available2015-11-24T19:36:13Z
dc.identifier.issn0031-3998-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23834
dc.rightsDefault Licence-
dc.subjectChild, Preschoolen
dc.subjectCongenital Abnormalities/*geneticsen
dc.subjectEuropean Continental Ancestry Group/*geneticsen
dc.subjectFemaleen
dc.subjectGene Frequencyen
dc.subjectGenotypeen
dc.subjectHumansen
dc.subjectInfanten
dc.subjectKidney/*abnormalitiesen
dc.subjectMaleen
dc.subject*Polymorphism, Geneticen
dc.subjectReceptor, Angiotensin, Type 2/*genetics/metabolismen
dc.subjectUrinary Tract/*abnormalitiesen
dc.titleAngiotensin II type 2 receptor gene polymorphism in Caucasian children with a wide spectrum of congenital anomalies of the kidney and urinary tracten
heal.abstractThe A-1332G transition of the angiotensin II type 2 receptor (AT2R) gene was found to occur more often in males with ureteropelvic (UPJO) or ureterovesical junction obstruction (UVJO). However, other studies have shown controversial results. Tauhe frequency of this polymorphism was investigated in 275 Caucasian children (153 boys, 122 girls) with a wide spectrum of congenital anomalies both of upper (165) and lower (110) urinary tract system and in 200 controls (100 boys, 100 girls). Among the included malformations, renal agenesis and duplex collecting system (DCS) were studied for the first time. The frequency of the G allele did not differ among patients (193 of 397 total alleles, 48.6%) and controls (146 of 300, 48.7%). No significant difference was also found in the frequency of the G allele in subgroups of congenital uropathies compared with controls. When analysis was performed in males and females separately, no significant difference was found in the frequency of the G allele in male (45.1%) or female (50.8%) patients compared with male (57.0%) or female (44.5%) controls. Our data indicate that the AT2R gene A-1332G transition is not associated with the development of human congenital uropathies and further investigations should be carried out to unravel their etiology.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1203/PDR.0b013e3180679101-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17515833-
heal.identifier.secondaryhttp://www.nature.com/pr/journal/v62/n1/pdf/pr2007175a.pdf-
heal.journalNamePediatr Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ