Uric acid elevation in atrial fibrillation

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dc.contributor.authorLetsas, K. P.en
dc.contributor.authorKorantzopoulos, P.en
dc.contributor.authorFilippatos, G. S.en
dc.contributor.authorMihas, C. C.en
dc.contributor.authorMarkou, V.en
dc.contributor.authorGavrielatos, G.en
dc.contributor.authorEfremidis, M.en
dc.contributor.authorSideris, A.en
dc.contributor.authorKardaras, F.en
dc.date.accessioned2015-11-24T18:57:19Z
dc.date.available2015-11-24T18:57:19Z
dc.identifier.issn1109-9666-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19154
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAtrial Fibrillation/*blooden
dc.subjectCross-Sectional Studiesen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectUric Acid/*blooden
dc.titleUric acid elevation in atrial fibrillationen
heal.abstractINTRODUCTION: Uric acid is a cardiovascular risk marker associated with oxidative stress and inflammation. Recently, atrial fibrillation (AF) has been associated with inflammation and oxidative stress. We therefore investigated the association between AF and uric acid levels. METHODS: Consecutive patients with AF and healthy control subjects were screened. Demographic, clinical, and echocardiographic characteristics were carefully recorded. In each participant, uric acid levels and conventional inflammatory markers were determined. The final study population consisted of 45 patients with paroxysmal AF, 41 patients with permanent AF, and 48 control subjects. RESULTS: A significant variance in uric acid levels was evident between patients with paroxysmal AF (5.7 +/- 1.1 mg/dl), permanent AF (6.7 +/- 1.4 mg/dl), and control subjects (5.1 +/- 1.3 mg/dl) (p<0.001). After univariate analysis considering 2 groups (control, AF patients), the following variables were significantly associated with the presence of AF: age, hypertension, -blocker use, low left ventricular ejection fraction (LVEF), increased left atrial diameter, uric acid levels, and C-reactive protein (CRP) levels. After multivariate logistic regression analysis, only CRP was an independent predictor for AF (odds ratio, OR: 2.172). In a subgroup analysis, CRP (OR: 1.434) and LVEF (OR: 0.361) were independent predictors of paroxysmal AF, while CRP (OR: 3.048), uric acid (OR: 2.172), and LVEF (OR: 0.34) were predictors of permanent AF. CONCLUSIONS: There is an association between increased levels of uric acid and permanent AF. Also, uric acid elevation may be related to the burden of AF. Undoubtedly, larger studies should further examine this potential association.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20515852-
heal.journalNameHellenic J Cardiolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2010-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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