Multinuclear 1D and 2D NMR investigations on the interaction between the pyrimidic nucleotides 5 '-CMP, 5 '-dCMP, and 5 '-UMP and diethyltin dichloride in aqueous medium

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dc.contributor.authorGhys, L.en
dc.contributor.authorBiesemans, M.en
dc.contributor.authorGielen, M.en
dc.contributor.authorGaroufis, A.en
dc.contributor.authorHadjiliadis, N.en
dc.contributor.authorWillem, R.en
dc.contributor.authorMartins, J. C.en
dc.date.accessioned2015-11-24T16:42:23Z
dc.date.available2015-11-24T16:42:23Z
dc.identifier.issn1434-1948-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8541
dc.rightsDefault Licence-
dc.subjecttinen
dc.subjectnucleotidesen
dc.subjectnmr spectrometryen
dc.subjectmass spectroscopyen
dc.subjectmultiple quantum nmren
dc.subjectx-ray-diffractionen
dc.subjectft-ir spectraen
dc.subjectsolid-stateen
dc.subjectorganotin compoundsen
dc.subjectcorrelation spectroscopyen
dc.subjectDNA-bindingen
dc.subjectnative DNAen
dc.subjectsn-119 nmren
dc.subjectcomplexesen
dc.titleMultinuclear 1D and 2D NMR investigations on the interaction between the pyrimidic nucleotides 5 '-CMP, 5 '-dCMP, and 5 '-UMP and diethyltin dichloride in aqueous mediumen
heal.abstractThe interactions between diethyltin dichloride and 5'-CMP, 5'-dCMP, and 5'-UMP in aqueous solution were investigated by multinuclear 1D and 2D NMR techniques including Sn-119, N-15 and P-31 nuclei. These studies were combined with electrospray mass spectrometry, infrared spectroscopy, solid state C-13, P-31 and Sn-117 CP-MAS NMRI and elemental analysis. As demonstrated by P-31-H-1 HOESY spectroscopy the diethyltin moiety interacts with the phosphate group of the pyrimidic mononucleotides in the pH range 0.5-3.5. Compound 8 (X = Cl), the solid isolated in this pH range from 5'-CMP, contains two tin atoms bridged by one oxygen and one chlorine atom, each tin atom being linked to the phosphate group of a nucleotide moiety. For 5'-UMP the solid isolated (12) has a dimeric structure with two different tin atoms; it can be formed by dimerization of compound it with the elimination of two water molecules. As demonstrated by H-1-Sn-119 HMQC correlation NMR data and the (2)J(Sn-119-O-Sn-117) coupling constant of 156 Hz, the diethyltin moiety reacts with the O(2') and O(3') oxygen atoms of the nucleotides to form a dimeric diethyldioxastannolane at pH > 9.0. Between pH 5.0 and 9.0, no evidence for any interaction between the diethyltin moiety and the nucleotides was found.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000085590100016-
heal.journalNameEuropean Journal of Inorganic Chemistryen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2000-
heal.publisherWiley-VCH Verlagen
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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