Two-dimensional 1H-NMR study of synthetic peptides containing the main immunogenic region of the Torpedo acetylcholine receptor
| dc.contributor.author | Cung, M. T. | en |
| dc.contributor.author | Marraud, M. | en |
| dc.contributor.author | Hadjidakis, I. | en |
| dc.contributor.author | Bairaktari, E. | en |
| dc.contributor.author | Sakarellos, C. | en |
| dc.contributor.author | Kokla, A. | en |
| dc.contributor.author | Tzartos, S. | en |
| dc.date.accessioned | 2015-11-24T19:01:51Z | |
| dc.date.available | 2015-11-24T19:01:51Z | |
| dc.identifier.issn | 0006-3525 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19732 | |
| dc.rights | Default Licence | - |
| dc.subject | Amino Acid Sequence | en |
| dc.subject | *Epitopes | en |
| dc.subject | Hydrogen | en |
| dc.subject | Magnetic Resonance Spectroscopy/methods | en |
| dc.subject | Molecular Sequence Data | en |
| dc.subject | *Oligopeptides/chemical synthesis | en |
| dc.subject | Protein Conformation | en |
| dc.subject | *Receptors, Cholinergic/immunology | en |
| dc.title | Two-dimensional 1H-NMR study of synthetic peptides containing the main immunogenic region of the Torpedo acetylcholine receptor | en |
| heal.abstract | A comparative 1H-NMR spectral study of a synthetic decapeptide containing the main immunogenic region of the Torpedo acetylcholine receptor (AChR; WNPADYGGIK, representing the alpha 67-76 fragment of Torpedo AChR) with four analogous peptides (WNP3-D5YGGIK, WNPAA5YGGIK, WNPADYGGA9K, and WNPD4DYGGV9K) has been carried out in dimethyl sulfoxide. One- and two-dimensional nmr experiments [correlated spectroscopy (COSY), relayed COSY, and phase-sensitive nuclear Overhauser enhancement spectroscopy (NOESY)] were performed to obtain complete assignments of the proton resonances. The presence of strong and multiple short- and long-range NOEs, and especially a strong long-range NOE between the two Asn2-C alpha H and Gly7-C alpha H protons, argues in favor of a rigid folded structure in all five cases. Temperature dependence measurements indicate the existence of three intramolecular interactions involving the Asp3, Gly8, and Lys10 amide protons. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1002/bip.360280141 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/2470436 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1002/bip.360280141/asset/360280141_ftp.pdf?v=1&t=h0aky8f7&s=f72ebd3b4ed3bdc13fe067ce61fb31af2d8e93d4 | - |
| heal.journalName | Biopolymers | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1989 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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