Sexual function in young women with spontaneous 46,XX primary ovarian insufficiency

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dc.contributor.authorKalantaridou, S. N.en
dc.contributor.authorVanderhoof, V. H.en
dc.contributor.authorCalis, K. A.en
dc.contributor.authorCorrigan, E. C.en
dc.contributor.authorTroendle, J. F.en
dc.contributor.authorNelson, L. M.en
dc.date.accessioned2015-11-24T18:51:47Z
dc.date.available2015-11-24T18:51:47Z
dc.identifier.issn1556-5653-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18309
dc.rightsDefault Licence-
dc.subjectAdministration, Cutaneousen
dc.subjectAdministration, Oralen
dc.subjectAdulten
dc.subjectCross-Sectional Studiesen
dc.subjectDouble-Blind Methoden
dc.subject*Estrogen Replacement Therapyen
dc.subjectEstrogens/administration & dosageen
dc.subjectFemaleen
dc.subjectGonadal Dysgenesis, 46,XX/*complications/geneticsen
dc.subjectHumansen
dc.subjectMedroxyprogesterone Acetate/administration & dosageen
dc.subjectPrimary Ovarian Insufficiency/*drug therapy/genetics/physiopathologyen
dc.subjectProspective Studiesen
dc.subjectQuestionnairesen
dc.subjectSexual Behavior/*drug effectsen
dc.subjectSexual Dysfunction, Physiological/genetics/physiopathology/*prevention & controlen
dc.subjectTestosterone/blooden
dc.subjectTreatment Outcomeen
dc.subjectYoung Adulten
dc.titleSexual function in young women with spontaneous 46,XX primary ovarian insufficiencyen
heal.abstractOBJECTIVE: To assess sexual function in women with spontaneous 46,XX primary ovarian insufficiency after at least 3 months of a standardized hormone replacement regimen. DESIGN: Cross-sectional cohort, controlled. SETTING: National Institutes of Health Clinical Research Center. PATIENT(S): Women with primary ovarian insufficiency (n = 143) and regularly menstruating controls (n = 70). INTERVENTION(S): Self-administered questionnaires, 100 microg/day E(2) patch, oral medroxyprogesterone acetate 10 mg for 12 days each month for patients. MAIN OUTCOME MEASURE(S): Derogatis Interview for Sexual Function Self-Report (DISF-SR). RESULT(S): Women with primary ovarian insufficiency had significantly lower DISF-SR composite scores compared with control women. Their serum total testosterone levels were significantly correlated with DISF-SR composite score, although this accounted for only 4% of the variance in this measure. Patients with testosterone levels below normal tended to have lower DISF-SR composite scores. Of patients with primary ovarian insufficiency, 9 of 127 (7%) scored below the second percentile on the composite sexual function score, compared with 1 of 49 control women (2%). CONCLUSION(S): As assessed by the DISF-SR, sexual function is in the normal range for most young women with 46,XX spontaneous primary ovarian insufficiency who are receiving physiologic E(2) replacement. However, as a group, these young women score significantly lower on this sexual function scale than control women.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.fertnstert.2007.08.040-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17961560-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0015028207032220/1-s2.0-S0015028207032220-main.pdf?_tid=480558dd76c8edb1902b9bccd4054684&acdnat=1333463344_82d769fa73ca20250f7aee4d23f4d51a-
heal.journalNameFertil Sterilen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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