Zinc(II) complexes of 2-acetyl pyridine 1-(4-fluorophenyl)-piperazinyl thiosemicarbazone: Synthesis, spectroscopic study and crystal structures - Potential anticancer drugs
Φόρτωση...
Ημερομηνία
Συγγραφείς
Stanojkovic, T. P.
Kovala-Demertzi, D.
Primikyri, A.
Garcia-Santos, I.
Castineiras, A.
Juranic, Z.
Demertzis, M. A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Inorg Biochem
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
2-Acetyl pyridine thiosemicarbazone containing an 1-(4-fluorophenyl)-piperazinyl ring incorporated at N(4)-position, HAcPipPheF (1) and the zinc(II) complexes [Zn(AcPipPheF)(2)] (2) and [Zn(OAc)(AcPipPheF)](2) (3) have been prepared and structurally characterized by means of vibrational and NMR ((1)H and (13)C) spectroscopy. The crystal structures of the compounds 1-3 have been determined by X-ray crystallography. The metal coordination geometry of [Zn(AcPipPheF)(2)] is described as distorted octahedral configuration in a trans-N-cis-N-cis-S configuration. In [Zn(OAc)(AcPipPheF)](2) one of the acetato group exhibits monoatomic bridge and the other bridges in a bidentate manner. The zinc(1) metal ion is coordinated in a distorted octahedral configuration while the metal coordination of Zn(2) is described as distorted square pyramidal. Biomedical studies revealed that, compounds 1-3 displayed potent anticancer activity. The antiproliferative activity of 1-3 was found to be considerably stronger than that of cis-platin. The IC(50) values range from 26 to 90 nM, against all cell lines tested, while for cis-platin the IC(50) values range from 2 to 17 mu M and for the zinc salt, ZnCl(2), the IC(50) values range from 81 to 93 mu M. The complex 3 shows the highest activity against all four cancer cell lines and the highest selectivity against K562 and MDA-MB-453 cancer cell lines. The compounds inhibited tumor cell proliferation by arresting the cell cycle progression at the S phase. (C) 2010 Elsevier Inc. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
zn(ii), complexes, thiosemicarbazone, crystal structure, in vitro antitumor activity, biological evaluation, rapid colorimetric assay, antitumor-activity, palladium(ii) complexes, platinum(ii) complexes, spectral properties, metal-complexes, in-vitro
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000274921200014
http://ac.els-cdn.com/S0162013410000036/1-s2.0-S0162013410000036-main.pdf?_tid=44fdb8c46a09fc4b6915fc4606fc5026&acdnat=1333028971_e4cb8d8dd0d0be54a70edb0bb617b948
http://ac.els-cdn.com/S0162013410000036/1-s2.0-S0162013410000036-main.pdf?_tid=44fdb8c46a09fc4b6915fc4606fc5026&acdnat=1333028971_e4cb8d8dd0d0be54a70edb0bb617b948
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας