A novel role of peripheral corticotropin-releasing hormone (CRH) on dermal fibroblasts

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dc.contributor.authorRassouli, O.en
dc.contributor.authorLiapakis, G.en
dc.contributor.authorLazaridis, I.en
dc.contributor.authorSakellaris, G.en
dc.contributor.authorGkountelias, K.en
dc.contributor.authorGravanis, A.en
dc.contributor.authorMargioris, A. N.en
dc.contributor.authorKaralis, K. P.en
dc.contributor.authorVenihaki, M.en
dc.date.accessioned2015-11-24T19:40:03Z
dc.date.available2015-11-24T19:40:03Z
dc.identifier.issn1932-6203-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24294
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectAntibodies, Neutralizing/immunologyen
dc.subjectApoptosisen
dc.subjectCell Movementen
dc.subjectCell Proliferationen
dc.subjectCorticotropin-Releasing Hormone/deficiency/*metabolismen
dc.subjectDermis/*cytologyen
dc.subjectFibroblasts/cytology/*metabolismen
dc.subjectHumansen
dc.subjectInterleukin-6/biosynthesis/immunologyen
dc.subjectMiceen
dc.subjectReceptors, Corticotropin-Releasing Hormone/metabolismen
dc.subjectTransforming Growth Factor beta1/biosynthesis/immunologyen
dc.titleA novel role of peripheral corticotropin-releasing hormone (CRH) on dermal fibroblastsen
heal.abstractCorticotropin-releasing hormone, or factor, (CRH or CRF) exerts important biological effects in multiple peripheral tissues via paracrine/autocrine actions. The aim of our study was to assess the effects of endogenous CRH in the biology of mouse and human skin fibroblasts, the primary cell type involved in wound healing. We show expression of CRH and its receptors in primary fibroblasts, and we demonstrate the functionality of fibroblast CRH receptors by induction of cAMP. Fibroblasts genetically deficient in Crh (Crh-/-) had higher proliferation and migration rates and compromised production of IL-6 and TGF-beta1 compared to the wildtype (Crh+/+) cells. Human primary cultures of foreskin fibroblasts exposed to the CRF(1) antagonist antalarmin recapitulated the findings in the Crh-/- cells, exhibiting altered proliferative and migratory behavior and suppressed production of IL-6. In conclusion, our findings show an important role of fibroblast-expressed CRH in the proliferation, migration, and cytokine production of these cells, processes associated with the skin response to injury. Our data suggest that the immunomodulatory effects of CRH may include an important, albeit not explored yet, role in epidermal tissue remodeling and regeneration and maintenance of tissue homeostasis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1371/journal.pone.0021654-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21765902-
heal.identifier.secondaryhttp://www.plosone.org/article/fetchObjectAttachment.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0021654&representation=PDF-
heal.journalNamePLoS Oneen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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