Treating dyslipidaemia in non-insulin-dependent diabetes mellitus -- a special reference to statins
Φόρτωση...
Ημερομηνία
Συγγραφείς
Papadakis, J. A.
Milionis, H. J.
Press, M.
Mikhailidis, D. P.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Diabetes Complications
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Patients with non-insulin-dependent diabetes (NIDDM) have an increased incidence of ischaemic heart disease (IHD) when compared with nondiabetic subjects. In addition, they have a worse prognosis after their first myocardial infarction (MI). According to the recent USA recommendations, the threshold for initiation of dietary intervention in diabetic subjects is an LDL greater than 2.6 mmol/l, with the goal to achieve levels less than 2.6 mmol/l (100 mg/dl). This is also the threshold for initiation and treatment goal for pharmacological intervention in diabetic subjects, unless they are completely free of IHD, peripheral vascular disease or cerebrovascular disease and have no other IHD risk factors. In the latter circumstances, the threshold for treatment is an LDL greater than 3.38 mmol/l (130 mg/dl), with the goal to achieve levels less than 3.38 mmol/l. The HMG-CoA reductase inhibitors (statins) can improve the lipid profile effectively and safely in NIDDM. Results from post hoc analyses of diabetic subgroups in the large intervention trials suggest that some statins significantly reduce the risk for IHD-related mortality/morbidity. However, because these results are derived from secondary prevention trials, we cannot be sure if these benefits apply to all diabetic subjects or only to those who already have IHD. Nevertheless, it seems logical to assume that this benefit also applies to NIDDM patients who do not have IHD because they share a similar vascular risk as nondiabetic subjects who have IHD. Intervention trials using statins and fibrates, alone or in combination, in NIDDM are under way. In a few years these trials will provide definitive end-point-based evidence in this high-risk group of patients.
Περιγραφή
Λέξεις-κλειδιά
Bezafibrate/therapeutic use, Clinical Trials as Topic, Diabetes Mellitus, Type 2/*complications/*physiopathology, Diabetic Angiopathies/physiopathology, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use, Hyperlipidemias/*drug therapy, Hypolipidemic Agents/*therapeutic use, Myocardial Infarction/complications/mortality/physiopathology, Myocardial Ischemia/epidemiology/*prevention & control
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/11457674
http://ac.els-cdn.com/S1056872701001398/1-s2.0-S1056872701001398-main.pdf?_tid=5d072ccfc6a0427756bed9536fcf0cc8&acdnat=1333952837_4f2271301701f34f0ee0d033e0bc5ac0
http://ac.els-cdn.com/S1056872701001398/1-s2.0-S1056872701001398-main.pdf?_tid=5d072ccfc6a0427756bed9536fcf0cc8&acdnat=1333952837_4f2271301701f34f0ee0d033e0bc5ac0
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής