Effects of adriamycin and cyclophosphamide treatment on induction of macrophage cytotoxic function in mice
| dc.contributor.author | Stoychkov, J. N. | en |
| dc.contributor.author | Schultz, R. M. | en |
| dc.contributor.author | Chirigos, M. A. | en |
| dc.contributor.author | Pavlidis, N. A. | en |
| dc.contributor.author | Goldin, A. | en |
| dc.date.accessioned | 2015-11-24T19:21:51Z | |
| dc.date.available | 2015-11-24T19:21:51Z | |
| dc.identifier.issn | 0008-5472 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22127 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | BCG Vaccine/pharmacology | en |
| dc.subject | Cyclophosphamide/*administration & dosage | en |
| dc.subject | Cytotoxicity, Immunologic/*drug effects | en |
| dc.subject | Dose-Response Relationship, Drug | en |
| dc.subject | Doxorubicin/*administration & dosage | en |
| dc.subject | Macrophages/*drug effects/immunology | en |
| dc.subject | Male | en |
| dc.subject | Mice | en |
| dc.subject | Mice, Inbred Strains | en |
| dc.subject | Pyran Copolymer/pharmacology | en |
| dc.subject | Time Factors | en |
| dc.title | Effects of adriamycin and cyclophosphamide treatment on induction of macrophage cytotoxic function in mice | en |
| heal.abstract | The effects of i.p. and s.c. Adriamycin and cyclophosphamide treatment of BALB/c x DBA/2F1 mice were studied alone and in combination with immunotherapeutic agents, pyran copolymer and Bacillus Calmette-Guerin, on macrophage cytotoxic ability, As assessed by direct viable cell counts of MBL-2 leukemia cells, both Adriamycin and cyclophosphamide produced growth-inhibitory macrophages. This function after s.c. cytostatic treatment peaked at Day 1 and decreased progressively, attaining normal control values by Day 6. When adjuvants, such as pyran and B. Calmette-Guerin, were administered i.p. simultaneously with s.c. Adriamycin or cyclophosphamide, adjuvant-induced cytotoxic function was not markedly affected. A better knowledge of the influence of cytostatic agents alone or combined with immunoadjuvants on macrophage cytotoxic ability may be useful in designing more effective chemoimmunotherapy protocols. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/455286 | - |
| heal.journalName | Cancer Res | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1979 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
Αρχεία
Φάκελος/Πακέτο αδειών
1 - 1 of 1
Φόρτωση...
- Ονομα:
- license.txt
- Μέγεθος:
- 1.74 KB
- Μορφότυπο:
- Item-specific license agreed upon to submission
- Περιγραφή: