Organotin flufenamates: Synthesis, characterization and antiproliferative activity of organotin flufenamates

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dc.contributor.authorKovala-Demertzi, D.en
dc.contributor.authorDokorou, V. N.en
dc.contributor.authorJasinski, J. P.en
dc.contributor.authorOpolski, A.en
dc.contributor.authorWiecek, J.en
dc.contributor.authorZervou, M.en
dc.contributor.authorDemertzis, M. A.en
dc.date.accessioned2015-11-24T16:43:35Z
dc.date.available2015-11-24T16:43:35Z
dc.identifier.issn0022-328X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8718
dc.rightsDefault Licence-
dc.subjectflufenamic aciden
dc.subjectdiorganotin flufenamatesen
dc.subjectcrystal structureen
dc.subjectspectroscopic studiesen
dc.subjectantitumor agentsen
dc.subjectnonsteroidal antiinflammatory drugsen
dc.subjectcrystal-structuresen
dc.subjectdiorganotin derivativesen
dc.subjectantituberculosis agentsen
dc.subjectmolecular-structuresen
dc.subjectcalcium influxen
dc.subjectmefenamic-aciden
dc.subject1st complexesen
dc.subjectin-vitroen
dc.subjectchemistryen
dc.titleOrganotin flufenamates: Synthesis, characterization and antiproliferative activity of organotin flufenamatesen
heal.abstractThe organotin flufenamates [Me(2)(flu)SnOSn(flu)Me(2)](2) (1), [Bu(2)(flu)SnOSn(flu)Bu(2)](2) (2) and [Bu(2)Sn(flu)(2)] (3) have been prepared and structurally characterized by means of vibrational and NMR ((1)H, (13)C and (119)Sn) spectroscopy. The crystal structure of [Me(2)(flu)SnOSn(flu)Me(2)](2) (1) has been determined by X-ray crystallography. Three distannoxane rings are present to the dimeric tetraorganodistannoxane of planar ladder arrangement. The structure is centro-symmetric and features a central rhombus Sn(2)O(2) unit with two additional tin atoms linked at the O atoms. Six-coordinated tin centers are present in the dimer distannoxane. This structure is self-assembled via pi -> pi and C-H -> pi stacking interactions. Flufenamic acid and flufenamates were evaluated for antiproliferative activity in vitro. Among the compounds tested [Bu(2)(flu)SnOSn(flu)Bu(2)](2) (2) and [Bu(2)Sn(flu)(2)] (3) exhibited high cytotoxic activity against the cancer cell line A549 (non-small cell lung carcinoma). (c) 2005 Elsevier B.V. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.jorganchem.2005.02.004-
heal.identifier.secondary<Go to ISI>://000228402700014-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0022328X05001221/1-s2.0-S0022328X05001221-main.pdf?_tid=76d88c05db7e6530df5080f397424513&acdnat=1333028709_78deec150926498022e5f830a24313da-
heal.journalNameJournal of Organometallic Chemistryen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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