Early ischemic preconditioning without hypotension prevents spinal cord injury caused by descending thoracic aortic occlusion
Φόρτωση...
Ημερομηνία
Συγγραφείς
Toumpoulis, I. K.
Anagnostopoulos, C. E.
Drossos, G. E.
Malamou-Mitsi, V. D.
Pappa, L. S.
Katritsis, D. G.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Thorac Cardiovasc Surg
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVE: Postoperative neurologic deficits after thoracic aortic reconstruction vary widely. Our previous study showed that delayed ischemic preconditioning could prevent spinal cord injury caused by occlusion of the descending thoracic aorta in pigs. We investigated early ischemic preconditioning in the same model. METHODS: Twenty-eight pigs were divided into 4 groups: group 1 (n = 6) underwent a sham operation, group 2 (n = 6) underwent aortic occlusion for 20 minutes, group 3 (n = 8) underwent aortic occlusion for 35 minutes, and group 4 (n = 8) underwent aortic occlusion for 20 minutes and underwent aortic occlusion 80 minutes later without hypotension for 35 minutes. Aortic occlusion was accomplished by using 2 balloon occlusion catheters placed fluoroscopically at T6 to T8 above the diaphragm and at the aortic bifurcation. Neurologic evaluation was performed by an independent observer according to the Tarlov scale (0-4). The lower thoracic and lumbar spinal cords were harvested at 120 hours and examined histologically with hematoxylin-and-eosin stain. Histologic results (number of neurons and grade of inflammation) were scored (0-4) and were similarly analyzed. Statistical analysis was by means of the Kruskal-Wallis test. RESULTS: Group 4 had a better neurologic outcome at 24, 48, and 120 hours in comparison with group 3 (P <.001). The histologic changes were proportional to the neurologic test scores, with the more severe and extensive gray matter damage in animals of group 3 (number of neurons, P <.001; grade of inflammation, P <.001). CONCLUSION: Early ischemic preconditioning without hypotension protects against spinal cord injury after aortic occlusion, as confirmed by using the Tarlov score and histopathology.
Περιγραφή
Λέξεις-κλειδιά
Animals, Aorta, Thoracic/pathology/*surgery, Aortic Diseases/*complications, Arterial Occlusive Diseases/*complications, Blood Pressure/physiology, Disease Models, Animal, *Ischemic Preconditioning, Spinal Cord/*blood supply, Spinal Cord Injuries/etiology/pathology/*prevention & control, Swine
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/12771875
http://ac.els-cdn.com/S0022522303501076/1-s2.0-S0022522303501076-main.pdf?_tid=6c589504451bd75a9184ceb76183ad53&acdnat=1333099529_456343a606143d6fe04a2dd022435676
http://ac.els-cdn.com/S0022522303501076/1-s2.0-S0022522303501076-main.pdf?_tid=6c589504451bd75a9184ceb76183ad53&acdnat=1333099529_456343a606143d6fe04a2dd022435676
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής