Expression of the RNA-binding protein CRD-BP in brain and non-small cell lung tumors

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dc.contributor.authorIoannidis, P.en
dc.contributor.authorKottaridi, C.en
dc.contributor.authorDimitriadis, E.en
dc.contributor.authorCourtis, N.en
dc.contributor.authorMahaira, L.en
dc.contributor.authorTalieri, M.en
dc.contributor.authorGiannopoulos, A.en
dc.contributor.authorIliadis, K.en
dc.contributor.authorPapaioannou, D.en
dc.contributor.authorNasioulas, G.en
dc.contributor.authorTrangas, T.en
dc.date.accessioned2015-11-24T16:33:18Z
dc.date.available2015-11-24T16:33:18Z
dc.identifier.issn0304-3835-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/7641
dc.rightsDefault Licence-
dc.subjectAdenocarcinoma/genetics/metabolismen
dc.subjectBrain/metabolismen
dc.subjectBrain Neoplasms/genetics/*metabolismen
dc.subjectCarcinoma, Large Cell/genetics/metabolismen
dc.subjectCarcinoma, Non-Small-Cell Lung/genetics/*metabolismen
dc.subjectCarcinoma, Squamous Cell/genetics/metabolismen
dc.subjectCase-Control Studieen
dc.titleExpression of the RNA-binding protein CRD-BP in brain and non-small cell lung tumorsen
heal.abstractThe coding region determinant-binding protein (CRD-BP) is an RNA binding protein that recognizes c-myc and IGF-II leader 3 mRNAs as well as the oncofetal H19 RNA. CRD-BP exhibits an oncofetal pattern of expression and has been detected in the majority of colon (81%), breast (58.5%) and sarcoma (73%) tumors. The study of CRD-BP expression was extended in brain tumors and Non small cell lung (NSCL) carcinomas and 12/24 malignant, 2/5 benign neuroepithelial tumors and 4/15 of NSCL carcinomas were found positive. All normal matching tissues tested were found negative. The highest frequency (60%) of CRD-BP positive tumors was observed in meningiomas, either benign (11/18) or atypical (3/3). These findings confirm that CRD-BP expression is restricted in tumors; the frequency of its de novo expression may vary according to tumor type and appears to be an early event in the transformation process.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.canlet.2003.12.015-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15159028-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0304383503008607/1-s2.0-S0304383503008607-main.pdf?_tid=70b9a4729ac76ed9c4fcbc69af2d3a30&acdnat=1337154616_3c6f97263669674a43ce54685e89b7fc-
heal.journalNameCancer Letten
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2004-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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