Synthesis, structural characterization and biological studies of the triphenyltin(IV) complex with 2-thiobarbituric acid

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dc.contributor.authorBalas, V. I.en
dc.contributor.authorVerginadis, , IIen
dc.contributor.authorGeromichalos, G. D.en
dc.contributor.authorKourkoumelis, N.en
dc.contributor.authorMale, L.en
dc.contributor.authorHursthouse, M. B.en
dc.contributor.authorRepana, K. H.en
dc.contributor.authorYiannaki, E.en
dc.contributor.authorCharalabopoulos, K.en
dc.contributor.authorBakas, T.en
dc.contributor.authorHadjikakou, S. K.en
dc.date.accessioned2015-11-24T19:43:25Z
dc.date.available2015-11-24T19:43:25Z
dc.identifier.issn1768-3254-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24753
dc.rightsDefault Licence-
dc.titleSynthesis, structural characterization and biological studies of the triphenyltin(IV) complex with 2-thiobarbituric aciden
heal.abstractThe reaction between 2-thiobarbituric acid (H(2)TBA), which was treated with an equimolar amount of potassium hydroxide, in a water with triphenytin chloride in methanol, results in the formation of the {[Ph(3)Sn(O-HTBA)]}(n) (1) complex. Crystals of the hydrated 1 with formula {[Ph(3)Sn(O-HTBA)].0.7(H(2)O)}(n) were growth from methanol/acetonitrile solution, of the white precipitation, filtered off, from the reaction. The crystal structure of complex 1 has been determined by X-ray diffraction at 120 K. Complex 1 is polymeric. The geometry around the tin(IV) ions is trigonal bi-pyramidal with coordination to three C atoms from phenyl groups and one O atom from a de-protonated HTBA ligand. Complex 1 and the already known [(n-Bu)(3)Sn(O-HTBA).H(2)O] (2) were evaluated for their in vitro cytotoxic activity (cell viability) against human cancer cell lines: HeLa (cervical), OAW-42 (ovarian), MCF-7 (breast, ER positive), MDA-MB-231 (breast, ER negative), A549 (lung), Caki-1 (renal) and additionally, the normal human lung cell line MRC-5 (normal human fetal lung fibroblast cells) and normal immortalized human mammary gland epithelial cell line MTSV17 with a Trypan Blue assay. Moreover complex 1 was evaluated for its in vitro cell growth proliferation activity against leiomyosarcoma cells (LMS), MCF-7 and MRC-5 cells with a Thiazolyl Blue Tetrazolium Bromide (MTT) assay. The type of cell death caused by complexes 1 and 2 was also evaluated by use of flow cytometry assay. The results showed that these compounds mediate a strong cytotoxic response to normal and cancer cell lines tested through apoptosis and induce cell cycle arrest in S phase of the cell cycle, suggesting DNA intercalation (direct or indirect) with the complexes. Finally, the influence of these complexes 1 and 2 upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was kinetically and theoretically studied.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.ejmech.2011.04.005-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21521629-
heal.identifier.secondaryhttp://ac.els-cdn.com/S022352341100290X/1-s2.0-S022352341100290X-main.pdf?_tid=8e2de272523c8f5235269f173e25e7a0&acdnat=1333448848_4b5207c8aa26b671c540840c44daca0d-
heal.journalNameEur J Med Chemen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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