Monte Carlo single-cell dosimetry of Auger-electron emitting radionuclides
| dc.contributor.author | Bousis, C. | en |
| dc.contributor.author | Emfietzoglou, D. | en |
| dc.contributor.author | Hadjidoukas, P. | en |
| dc.contributor.author | Nikjoo, H. | en |
| dc.date.accessioned | 2015-11-24T19:03:51Z | |
| dc.date.available | 2015-11-24T19:03:51Z | |
| dc.identifier.issn | 1361-6560 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19938 | |
| dc.rights | Default Licence | - |
| dc.subject | Antibodies, Monoclonal | en |
| dc.subject | Cell Line, Tumor | en |
| dc.subject | Cell Nucleus/radiation effects | en |
| dc.subject | *Electrons | en |
| dc.subject | Humans | en |
| dc.subject | Lymphoma, B-Cell/pathology/radiotherapy | en |
| dc.subject | *Monte Carlo Method | en |
| dc.subject | Radiation Dosage | en |
| dc.subject | Radioisotopes/*therapeutic use | en |
| dc.subject | Radiometry/*methods | en |
| dc.title | Monte Carlo single-cell dosimetry of Auger-electron emitting radionuclides | en |
| heal.abstract | A hybrid Monte Carlo transport scheme combining event-by-event and condensed-history simulation with a full account of energy-loss straggling was used to study the dosimetric characteristics of the Auger-emitting radionuclides 67Ga, 99mTc, 111In, 123I, 125I and 201Tl at the single-cell level. The influence of the intracellular localization of the Auger radionuclide upon cellular S-values, radial dose rate profiles and dose-volume-histograms (DVHs) was investigated. For the case where the radiopharmaceutical was either internalized into the cytoplasm or remained bound onto the cell surface (non-internalized), the dose to the cell nucleus was found to differ significantly from the MIRD values and other published data. In this case, the assumption of a homogeneous distribution throughout the cell is shown to significantly overestimate the nuclear dose. A dosimetric case study relevant to the radioimmunotherapy of single lymphoma B-cells with 125I and 123I is presented. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1088/0031-9155/55/9/009 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/20393237 | - |
| heal.identifier.secondary | http://iopscience.iop.org/0031-9155/55/9/009/pdf/0031-9155_55_9_009.pdf | - |
| heal.journalName | Phys Med Biol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2010 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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