Corticotropin-releasing hormone (CRH) and immunotolerance of the fetus

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dc.contributor.authorMakrigiannakis, A.en
dc.contributor.authorZoumakis, E.en
dc.contributor.authorKalantaridou, S.en
dc.contributor.authorMitsiades, N.en
dc.contributor.authorMargioris, A.en
dc.contributor.authorChrousos, G. P.en
dc.contributor.authorGravanis, A.en
dc.date.accessioned2015-11-24T19:26:37Z
dc.date.available2015-11-24T19:26:37Z
dc.identifier.issn0006-2952-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22744
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectApoptosisen
dc.subjectCell Differentiationen
dc.subjectCorticotropin-Releasing Hormone/*immunology/metabolismen
dc.subjectDecidua/cytologyen
dc.subjectEmbryo Implantationen
dc.subjectEndometrium/metabolismen
dc.subjectFemaleen
dc.subjectFetus/cytology/*immunologyen
dc.subjectHumansen
dc.subject*Immune Toleranceen
dc.titleCorticotropin-releasing hormone (CRH) and immunotolerance of the fetusen
heal.abstractThe hypothalamic neuropeptide corticotropin-releasing hormone (CRH) is produced by several tissues of the female reproductive system, including the endometrial glands and decidualized stroma, as well as the trophoblast, syncytiotrophoblast, and placental decidua. CRH is also secreted at inflammatory sites and possesses potent pro-inflammatory properties influencing both innate and acquired immune processes. Recent experimental findings show that uterine CRH participates in local immune phenomena associated with early pregnancy, such as differentiation of endometrial stroma to decidua and protection of the fetus from the maternal immune system. CRH induces the expression of apoptotic Fas ligand (FasL) on invasive extravillous trophoblast and maternal decidual cells at the fetal-maternal interface. Furthermore, CRH increases the apoptosis of activated T lymphocytes through FasL induction, participating in the processes of both implantation and early pregnancy tolerance.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12623122-
heal.journalNameBiochem Pharmacolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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