Renal function in premature infants during aminoglycoside therapy

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dc.contributor.authorGiapros, V. I.en
dc.contributor.authorAndronikou, S.en
dc.contributor.authorCholevas, V. I.en
dc.contributor.authorPapadopoulou, Z. L.en
dc.date.accessioned2015-11-24T18:54:20Z
dc.date.available2015-11-24T18:54:20Z
dc.identifier.issn0931-041X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18672
dc.rightsDefault Licence-
dc.subjectAmikacin/*adverse effects/therapeutic useen
dc.subjectCalcium/urineen
dc.subjectCase-Control Studiesen
dc.subjectCreatinine/metabolismen
dc.subjectGentamicins/*adverse effects/therapeutic useen
dc.subjectHumansen
dc.subjectInfant, Newbornen
dc.subjectInfant, Premature, Diseases/*drug therapyen
dc.subjectInfection/*drug therapyen
dc.subjectKidney/*drug effects/physiologyen
dc.subjectKidney Function Testsen
dc.subjectMagnesium/metabolismen
dc.subjectNetilmicin/*adverse effects/therapeutic useen
dc.subjectPhosphorus/metabolismen
dc.subjectPotassium/metabolismen
dc.subjectSodium/metabolismen
dc.subjectUric Acid/metabolismen
dc.titleRenal function in premature infants during aminoglycoside therapyen
heal.abstractThe effect of three different aminoglycosides on renal function was evaluated in 30 premature infants of similar gestational age who were treated within 24 h of birth with either amikacin (10 infants, group A), gentamicin (10 infants, group B) or netilmicin (10 infants, group C), for a period of 7 days. Ten infection-free premature infants of similar post-conceptional age were used as controls. Serial determinations of plasma creatinine concentration (PCr), as well as the fractional excretion of sodium (FENa), potassium, magnesium (FEMg), phosphate (FEP) and uric acid (FEUA), and the urinary excretion of calcium (UCa/UCr ratio) were assessed before, during and after treatment. During the treatment period a significant increase in FENa, FEMg and UCa/UCr was observed in group B (P < 0.05 and P < 0.01, respectively) and an increase in FENa and UCa/UCr in group C (P < 0.01) compared with controls. These disturbances were observed with trough concentrations of aminoglycosides but were accentuated at peak serum concentrations and were restored to normal 2 days after stopping therapy. In addition, a significant correlation was demonstrated between FENa, FEMg and UCa/UCr ratio in treated patients. PCr levels decreased similarly in all patient groups, but in 8 of 30 infants (27%) they remained elevated and returned to control values only 10 days after stopping therapy. Such renal functional disturbances, although transient, may result in significant electrolyte and mineral imbalance in the sick premature infant.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/7794710-
heal.identifier.secondaryhttp://www.springerlink.com/content/u3702647xq142316/fulltext.pdf-
heal.journalNamePediatr Nephrolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1995-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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