Prosthesis infection: diagnosis after total joint arthroplasty with antigranulocyte scintigraphy with 99mTc-labeled monoclonal antibodies--a meta-analysis

Απλή σελίδα τεκμηρίου
dc.contributor.authorPakos, E. E.en
dc.contributor.authorTrikalinos, T. A.en
dc.contributor.authorFotopoulos, A. D.en
dc.contributor.authorIoannidis, J. P.en
dc.date.accessioned2015-11-24T18:55:58Z
dc.date.available2015-11-24T18:55:58Z
dc.identifier.issn0033-8419-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18961
dc.rightsDefault Licence-
dc.subjectAntibodies, Monoclonal/*diagnostic useen
dc.subjectArthroplasty, Replacement/*statistics & numerical dataen
dc.subjectClinical Trials as Topic/statistics & numerical dataen
dc.subjectGranulocytesen
dc.subjectHumansen
dc.subjectIsoantigens/immunologyen
dc.subjectPrevalenceen
dc.subjectPrognosisen
dc.subjectProsthesis Failureen
dc.subjectProsthesis-Related Infections/*epidemiology/*radionuclide imagingen
dc.subjectRadiopharmaceuticals/diagnostic useen
dc.subjectReproducibility of Resultsen
dc.subjectRisk Assessment/*methodsen
dc.subjectRisk Factorsen
dc.subjectSensitivity and Specificityen
dc.subjectTechnetium/*diagnostic useen
dc.titleProsthesis infection: diagnosis after total joint arthroplasty with antigranulocyte scintigraphy with 99mTc-labeled monoclonal antibodies--a meta-analysisen
heal.abstractPURPOSE: To perform a meta-analysis of diagnostic studies regarding the accuracy of antigranulocyte scintigraphy (AGS) with monoclonal antibodies in the identification of prosthesis infection after total hip or knee arthroplasty. MATERIALS AND METHODS: PubMed and EMBASE searches were conducted for the identification of relevant studies. Data on the diagnostic performance of AGS with monoclonal antibodies were combined quantitatively across eligible studies, and the overall sensitivity and specificity, along with summary receiver operating characteristic (ROC) curves and likelihood ratios (LRs), were estimated. The above parameters were evaluated for all patients and for various subgroups among the eligible studies. The reference standard used in the individual studies was accepted. RESULTS: Thirteen eligible studies on nonoverlapping patient groups were included in the meta-analysis; there was a total sample size of 522 implants. The independent random effects summary estimates of sensitivity and specificity were 83% and 80%, respectively. The summary ROC curve estimate for weighted analysis was a sensitivity of 90% for a specificity of 80%. LR syntheses gave a weighted positive LR of 3.99 (95% confidence interval [CI]: 3.13, 5.09) and a weighted negative LR of 0.22 (95% CI: 0.15, 0.34); there was no statistically significant between-study heterogeneity for either metric. Various subgroup analyses did not reveal any statistically significant differences. CONCLUSION: AGS with monoclonal antibodies had a reasonably high discriminating ability to identify prosthesis infection in patients who underwent total joint arthroplasty.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1148/radiol.2421052011-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17090716-
heal.identifier.secondaryhttp://radiology.rsna.org/content/242/1/101.full.pdf-
heal.journalNameRadiologyen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ