Global vasomotor dysfunction and accelerated vascular aging in beta-thalassemia major
Φόρτωση...
Ημερομηνία
Συγγραφείς
Hahalis, G.
Kremastinos, D. T.
Terzis, G.
Kalogeropoulos, A. P.
Chrysanthopoulou, A.
Karakantza, M.
Kourakli, A.
Adamopoulos, S.
Tselepis, A. D.
Grapsas, N.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Atherosclerosis
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Background: Patients with beta-thalassemia major (beta-TM) demonstrate an increased incidence of vascular complications, which are thought to result from a procoagulant/proinflammatory environment. We investigated the arterial vasorelaxing capacity and sought for early carotid atherosclerosis and underlying pathophysiological correlates in these transfusion-dependent patients. Methods and results: The vasodilatory properties of the brachial artery and the carotid intima-media thickness (IMT) were examined with ultrasonography in 35 non-diabetic young adults with beta-TM (patient group) and 35 control subjects (control group). Among thalassemic patients, both endothelium-dependent (FMD) and -independent dilatation (FID) as well as their ratio was impaired, whereas IMT was increased (p<0.01). Patients on optimal, as compared with those on non-optimal chelation treatment had a non-significantly lower IMT. Vasodilatory capacity in the patient group was inversely correlated with IMT and independently associated either with the quality of chelation therapy (FMD) or serum ferritin levels (FID). Plasma concentrations of D-dimers, circulating markers of endothelial activation, inflammation and apoptosis were higher, while plasma cholesterol and fibrinogen levels were lower-than-normal in the patient group. Independent predictors of IMT among thalassemic patients were tumor necrosis factor-alpha levels and age. Conclusions: Young adults with beta-TM exhibit both a global impairment of arterial vasorelaxation and early carotid atherosclerosis. A procoagulant/proinflammatory state in these transfusion-dependent patients may overwhelm atheroprotective mechanisms, including an optimal chelation regimen, and promote vascular injury and atherogenesis. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
thalassemia, carotid atherosclerosis, endothelium, iron-overload, inflammation, necrosis-factor-alpha, intima-media thickness, coronary-artery-disease, blood mononuclear-cells, oxidative stress, endothelial dysfunction, carotid atherosclerosis, immune status, pseudoxanthoma elasticum, peripheral-blood
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000257133600028
http://ac.els-cdn.com/S0021915007005928/1-s2.0-S0021915007005928-main.pdf?_tid=e39b64b8233a2637e82eb062d64fee2c&acdnat=1333111284_a69e94e77c9bee320c75cf6f091f5c9a
http://ac.els-cdn.com/S0021915007005928/1-s2.0-S0021915007005928-main.pdf?_tid=e39b64b8233a2637e82eb062d64fee2c&acdnat=1333111284_a69e94e77c9bee320c75cf6f091f5c9a
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας