Hybridization and cellular uptake properties of lipophilic oligonucleotide-dendrimer conjugates
| dc.contributor.author | Skobridis, K. | en |
| dc.contributor.author | Husken, D. | en |
| dc.contributor.author | Nicklin, P. | en |
| dc.contributor.author | Haner, R. | en |
| dc.date.accessioned | 2015-11-24T16:39:10Z | |
| dc.date.available | 2015-11-24T16:39:10Z | |
| dc.identifier.issn | 1424-6376 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/8126 | |
| dc.rights | Default Licence | - |
| dc.subject | antisense oligonucleotides | en |
| dc.subject | oligonucleotide-dendrimer conjugates | en |
| dc.subject | hybridization | en |
| dc.subject | cellular uptake | en |
| dc.subject | antisense oligonucleotides | en |
| dc.subject | gene-transfer | en |
| dc.subject | sirnas | en |
| dc.subject | cancer | en |
| dc.subject | oligodeoxyribonucleotide | en |
| dc.subject | oligodeoxynucleotides | en |
| dc.subject | strategies | en |
| dc.title | Hybridization and cellular uptake properties of lipophilic oligonucleotide-dendrimer conjugates | en |
| heal.abstract | Dendrimeric compounds were conjugated to oligonucleotides in order to improve their cellular uptake. Second and third generation lipophilic dendrimers were covalently attached either to the 5'- or 3'- end of oligonucleotides. Thermal denaturation experiments showed that the attachment of a third generation dendrimer leads to a substantial decrease in binding affinity. The considerably smaller second-generation dendrimers, however, are well tolerated. Fluorescence measurements revealed that the presence of a second-generation dendrimer leads to a marked increase in the cellular uptake of oligonucleotides. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | <Go to ISI>://000233931300040 | - |
| heal.journalName | Arkivoc | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2005 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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