Patient's age modifies the impact of the proposed predictors of sustained virological response in chronic hepatitis C patients treated with PEG-interferon plus ribavirin

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dc.contributor.authorElefsiniotis, I. S.en
dc.contributor.authorPavlidis, C.en
dc.contributor.authorKetikoglou, I.en
dc.contributor.authorKoutsounas, S.en
dc.contributor.authorScarmeas, N.en
dc.contributor.authorPantazis, K. D.en
dc.contributor.authorMoulakakis, A.en
dc.contributor.authorTsianos, E. V.en
dc.date.accessioned2015-11-24T18:59:53Z
dc.date.available2015-11-24T18:59:53Z
dc.identifier.issn1879-0828-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19434
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAge Factorsen
dc.subjectAgeden
dc.subjectAntiviral Agents/*administration & dosageen
dc.subjectBiopsy, Needleen
dc.subjectFemaleen
dc.subjectForecastingen
dc.subjectGenotypeen
dc.subjectGreeceen
dc.subjectHepatitis C, Chronic/*drug therapyen
dc.subjectHumansen
dc.subjectInterferon-alpha/*administration & dosageen
dc.subjectLiver/*pathology/virologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPolyethylene Glycols/*administration & dosageen
dc.subjectRecombinant Proteinsen
dc.subjectRetrospective Studiesen
dc.subjectRibavirin/*administration & dosageen
dc.subjectTreatment Outcomeen
dc.subjectViral Loaden
dc.titlePatient's age modifies the impact of the proposed predictors of sustained virological response in chronic hepatitis C patients treated with PEG-interferon plus ribavirinen
heal.abstractBACKGROUND: The aim of this study was to investigate the effect of patient's age on the impact of typically proposed predictors of sustained virological response (SVR) in treatment-naive, high-pretreatment viral load (>700.000 IU/ml), chronic hepatitis C (CHC) patients treated under real-life conditions in Greece. METHODS: We retrospectively analyzed 185 CHC patients (14.4% cirrhotics) who had been treated with weight-adjusted dosing (1.5 microg/kg per week) of pegylated interferon-a2b (PEG) plus genotype-based ribavirin (RIB) for 24 or 48 weeks of treatment, based on viral genotype. SVR was confirmed by undetectable serum HCV-RNA 6 months after the end of treatment. RESULTS: Overall, 68.5% of patients exhibited SVR and 31.5% were non-responders (non-SVRs). Among the non-SVRs, 71.4% were infected with HCV genotype-1. Importantly, 71.4% of genotype 4-infected treated patients exhibited SVR. In the multivariate analyses, only the early histological stage of liver disease (p=0.015) and the presence of genotype non-1 infection (p=0.003) were independent predictors of SVR. For patients younger than 35 years, none of the baseline parameters and neither viral genotype (p=0.284) nor the stage of liver disease (p=0.351) was an independent predictor of non-SVR, whereas for patients between 35 and 55, only the presence of genotype-1 infection independently predicted non-SVR (p=0.008). For older patients (>55 years), only the histological stage of liver disease (p=0.047) and not the viral genotype (p=0.275) independently predicted non-SVR. CONCLUSIONS: The impact of the typical predictors of SVR, such as viral genotype and liver histopathology, is modified according to patient's age in currently approved combination treatment.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.ejim.2007.06.014-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18471675-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0953620507003536/1-s2.0-S0953620507003536-main.pdf?_tid=cdf2ffe3539831b8de5652fae8a8d0a5&acdnat=1333694941_c5bbe4009e00fe3f233c6e79d5ecceb5-
heal.journalNameEur J Intern Meden
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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