Anticardiolipin antibodies in unselected autoimmune rheumatic disease patients
| dc.contributor.author | Manoussakis, M. N. | en |
| dc.contributor.author | Gharavi, A. E. | en |
| dc.contributor.author | Drosos, A. A. | en |
| dc.contributor.author | Kitridou, R. C. | en |
| dc.contributor.author | Moutsopoulos, H. M. | en |
| dc.date.accessioned | 2015-11-24T19:36:04Z | |
| dc.date.available | 2015-11-24T19:36:04Z | |
| dc.identifier.issn | 0090-1229 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23801 | |
| dc.rights | Default Licence | - |
| dc.subject | Adolescent | en |
| dc.subject | Adult | en |
| dc.subject | Aged | en |
| dc.subject | Aged, 80 and over | en |
| dc.subject | Autoantibodies/*analysis/immunology | en |
| dc.subject | Autoimmune Diseases/*immunology | en |
| dc.subject | Cardiolipins/*immunology | en |
| dc.subject | Enzyme-Linked Immunosorbent Assay | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Immunoglobulin G/analysis | en |
| dc.subject | Immunoglobulin M/analysis | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Rheumatic Diseases/*immunology | en |
| dc.subject | Thromboembolism/*immunology | en |
| dc.title | Anticardiolipin antibodies in unselected autoimmune rheumatic disease patients | en |
| heal.abstract | Quantitative determination of IgG and IgM antibodies to cardiolipin (anti-CL) was performed with a newly developed sensitive and specific ELISA method. We studied a cohort of 361 unselected patients with various autoimmune rheumatic diseases (ARD), 69 patients with thromboembolic phenomena (TEP) unassociated with ARD, and 267 healthy blood donors (HBD). Anti-CL of at least one immunoglobulin class were found in 42 (11.6%) of the ARD patients, in 3 (4.3%) of the TEP patients (2 with myocardial infarction and 1 with pulmonary emboli), and in 6 (2.3%) of the HBD. In ARD patients anti-CL were more prevalent in patients with systemic lupus erythematosus (SLE) and overlap syndromes. Significant correlations included CNS involvement (particularly seizures) and features of immune hyperreactivity (splenomegaly-lymphadenopathy, ANA, and antibodies to Ro(SSA), U1-nRNP, and double-stranded DNA). No statistical correlation could be demonstrated between the presence of anti-CL and thrombotic events, hematologic disorders, or recurrent abortions in the ARD patients. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/3497746 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/0090122987900730/1-s2.0-0090122987900730-main.pdf?_tid=7a55ad966616f2ac11874dacb2d2daaa&acdnat=1333524872_e3f75cf44de4bd97282ffd4a6244c16e | - |
| heal.journalName | Clin Immunol Immunopathol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1987 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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