Synthesis, study, and structural characterization of a new water soluble hexanuclear silver(I) cluster with the 2-mercapto-nicotinic acid with possible antiviral activity
| dc.contributor.author | Zachariadis, P. C. | en |
| dc.contributor.author | Hadjikakou, S. K. | en |
| dc.contributor.author | Hadjiliadis, N. | en |
| dc.contributor.author | Michaelides, A. | en |
| dc.contributor.author | Skoulika, S. | en |
| dc.contributor.author | Ming, Y. | en |
| dc.contributor.author | Xiaolin, Y. | en |
| dc.date.accessioned | 2015-11-24T16:49:53Z | |
| dc.date.available | 2015-11-24T16:49:53Z | |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9540 | |
| dc.rights | Default Licence | - |
| dc.subject | Bioinorganic chemistry | en |
| dc.subject | Silver(I) complexes | en |
| dc.subject | 2-Mercapto-nicotinic acid | en |
| dc.subject | Crystal structures | en |
| dc.subject | Anti-HIV-RT activity | en |
| dc.title | Synthesis, study, and structural characterization of a new water soluble hexanuclear silver(I) cluster with the 2-mercapto-nicotinic acid with possible antiviral activity | en |
| heal.abstract | Silver(I) chloride reacts with 2-mercapto-nicotinic acid (H2mna, C6H5NO2S) in the presence of an excess of triethylamine in DMSO to form a hexanuclear, water soluble, cluster of formula {[Ag6(m3-Hmna)4(m3-mna)2]2 /[(Et3NH) ]2 /(DMSO)2 /(H2O)} (1). The complex 1 was characterized by elemental analyses, and FT-IR, UV /Vis and 1H NMR spectroscopy. Crystal structures of complex 1 and the ligand, 2-mecapto-nicotinic acid (2), have been determined by X-ray diffraction. Compound 1, C52H68Ag6- N8O15S8, is monoclinic with a space group P21/c (No. 14) and a /11.7080(10), b /16.2920(10), c /18.3010(10) A Β° , b /91.350(10)8, Z /4. The entire molecule is ionic and consists of a double anionic hexa-nuclear cluster and two protonated triethylamine counter cations while it is solvated by two DMSO and one water molecule. The 2-mercapto-nicotinic acid (2), C6H5NO2S, is orthorhombic (space group Pna21 (No. 33), a /8.3910(10), b /13.2720(10), c /5.892 A Β° , Z /4). An extended inter-molecular hydrogen bonding via O H /N contacts (O(1) H(5)[N(5)] /1.8998, O(1) N(5) /2.8049 A Β° ) links the molecules forming a supramolecular twodimensional network. Complex 1, was evaluated for anti-HIV-RT activity. It was found to inhibit the human immunodeficiency viral replication reverse transcriptase (HIV-RT) with calculated inhibiting concentration (IC50) 0.012759/0.00115 mg ml 1. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.sciencedirect.com/science/article/pii/S0020169302012100# | - |
| heal.journalName | Inorganica Chimica Acta | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2003 | - |
| heal.publisher | Elsevier | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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