Adenovirus-mediated delivery of antisense gene to urokinase-type plasminogen activator receptor suppresses glioma invasion and tumor growth

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dc.contributor.authorMohan, P. M.en
dc.contributor.authorChintala, S. K.en
dc.contributor.authorMohanam, S.en
dc.contributor.authorGladson, C. L.en
dc.contributor.authorKim, E. S.en
dc.contributor.authorGokaslan, Z. L.en
dc.contributor.authorLakka, S. S.en
dc.contributor.authorRoth, J. A.en
dc.contributor.authorFang, B.en
dc.contributor.authorSawaya, R.en
dc.contributor.authorKyritsis, A. P.en
dc.contributor.authorRao, J. S.en
dc.date.accessioned2015-11-24T19:37:38Z
dc.date.available2015-11-24T19:37:38Z
dc.identifier.issn0008-5472-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24057
dc.rightsDefault Licence-
dc.subjectAdenoviridae/*geneticsen
dc.subjectAnimalsen
dc.subjectBrain Neoplasms/pathology/*therapyen
dc.subjectDNA, Antisense/*geneticsen
dc.subjectDisease Progressionen
dc.subject*Gene Therapyen
dc.subjectGlioblastoma/pathology/*therapyen
dc.subjectHumansen
dc.subjectMiceen
dc.subjectMice, Nudeen
dc.subjectNeoplasm Invasivenessen
dc.subjectNeoplasm Proteins/antagonists & inhibitors/*geneticsen
dc.subjectNeoplasm Transplantationen
dc.subjectOrganoidsen
dc.subjectRatsen
dc.subjectReceptors, Cell Surface/antagonists & inhibitors/*geneticsen
dc.subjectReceptors, Urokinase Plasminogen Activatoren
dc.subjectTumor Cells, Cultureden
dc.titleAdenovirus-mediated delivery of antisense gene to urokinase-type plasminogen activator receptor suppresses glioma invasion and tumor growthen
heal.abstractThe urokinase-type plasminogen activator (uPA) and uPA receptor (UPAR) play important roles in the proteolytic cascade involved in the invasiveness of gliomas and other invasive tumors. High-level expression of uPAR has been correlated with high-grade glioma cell lines and tumors We report here that down-regulating uPAR levels by antisense strategy using an adenovirus construct (Ad-uPAR) inhibited glioma invasion in Matrigel and spheroid in vitro models. sc. (U87-MG) and intracranial (SNB19) injections of Ad-uPAR-infected glioma cells did not produce tumors in nude mice. However, injection of the Ad-uPAR construct into previously established so U87-MG tumors in nude mice caused regression of those tumors. Our results support the therapeutic potential of targeting the uPA-uPAR system for the treatment of gliomas and other cancers.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10416596-
heal.identifier.secondaryhttp://cancerres.aacrjournals.org/content/59/14/3369.full.pdf-
heal.journalNameCancer Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1999-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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