Changing serological status and low vaccination-induced protection rates against hepatitis B characterize chronic hepatitis C virus-infected injecting drug users in Greece: need for immunization policy

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dc.contributor.authorElefsiniotis, I. S.en
dc.contributor.authorPantazis, K. D.en
dc.contributor.authorKetikoglou, I. D.en
dc.contributor.authorKoutsounas, S. I.en
dc.contributor.authorTsianos, E. V.en
dc.date.accessioned2015-11-24T19:30:55Z
dc.date.available2015-11-24T19:30:55Z
dc.identifier.issn0954-691X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23184
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAntibodies, Viral/blooden
dc.subjectChi-Square Distributionen
dc.subjectFemaleen
dc.subjectGenotypeen
dc.subjectGreeceen
dc.subject*Hepacivirus/genetics/immunologyen
dc.subjectHepatitis B/immunology/*prevention & controlen
dc.subjectHepatitis B Vaccines/*administration & dosageen
dc.subjectHepatitis B virus/*immunologyen
dc.subjectHepatitis C, Chronic/*immunology/virologyen
dc.subjectHumansen
dc.subjectImmunization Programsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectSeroepidemiologic Studiesen
dc.subjectSerologic Testsen
dc.subjectSubstance Abuse, Intravenous/*immunology/virologyen
dc.subjectTimeen
dc.titleChanging serological status and low vaccination-induced protection rates against hepatitis B characterize chronic hepatitis C virus-infected injecting drug users in Greece: need for immunization policyen
heal.abstractOBJECTIVE: To evaluate the serological status of hepatitis B virus infection among Greek injecting drug users with chronic hepatitis C virus infection; to correlate hepatitis B virus infection status with the possible time of infection and the principal genotype of hepatitis C virus infection. METHODS: Two hundred and thirty consecutive injecting drug users with chronic hepatitis C virus infection were evaluated for serological markers of hepatitis B virus infection. One hundred and three of them (44.8%) reported intravenous drug use beginning before 1992 (group A) and 127/230 (55.2%) after 1992 (group B). Statistical analysis of data was based on Student's t-test and chi analyses. RESULTS: Eighty-five of 103 patients from group A (82.5%) and 28/127 (22%) from group B had serological markers of previous hepatitis B virus infection (P<0.001). Eleven patients from group A (10.6%) and 78 (61.4%) from group B were seronegative for all hepatitis B virus markers (P<0.001). Only 3.8% (4/103) of group A patients and 16.5% (21/127) of group B had vaccination-induced protective antibody levels (anti-HBs) against hepatitis B (P=0.02). The majority of patients were infected with hepatitis C virus genotype-3 (64.7% from group A vs 56.7% from group B, P=0.42). The percentages of patients infected with genotype-1 were also comparable in both groups (15.5% from group A vs 30.8% from group B, P=0.09). A significantly higher percentage of group A patients were infected with genotype-4 (19.7%) than those in group B (4.9%, P=0.02). CONCLUSION: The serological profile of hepatitis B virus infection among Greek hepatitis C virus-infected injecting drug users is changing. The proportion of successfully vaccinated hepatitis B virus injecting drug users, although significantly higher than the previous decades, is still relatively low. Vaccination policy in this high-risk group for viral hepatitis is urgently needed.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1097/01.meg.0000236888.51838.36-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17033445-
heal.journalNameEur J Gastroenterol Hepatolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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